Poudou C, Baffet H, Nadeau C, Rolland A-L, Catteau-Jonard S, Robin G
Service gynécologie obstétrique et médecine de la reproduction, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
Service de gynécologie médicale, orthogénie et sexologie, hôpital Jeanne-de-Flandre, CHU de Lille, avenue Eugène-Avinée, 59073 Lille cedex, France; Service d'assistance médicale à la procréation et préservation de la fertilité, CHU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France.
Gynecol Obstet Fertil Senol. 2021 May;49(5):462-473. doi: 10.1016/j.gofs.2021.03.031. Epub 2021 Mar 23.
The use of hormone replacement therapy (HRT) for menopausal women has been the subject of much controversy in recent years, particularly concerning the carcinologic risks. The purpose of this review is to evaluate the impact of the use of HRT on the risk of gynecological but also extra-gynecological cancers. The effect of the type and the duration of use of HRT in menopausal women will also be discussed. The beneficial impact of HRT on overall mortality is also an element that will be discussed and must be taken into account when evaluating the benefit-risk balance of HRT for menopausal women.
近年来，更年期女性使用激素替代疗法（HRT）一直备受争议，尤其是在致癌风险方面。本综述的目的是评估使用HRT对妇科癌症以及妇科以外癌症风险的影响。还将讨论HRT类型和使用持续时间对更年期女性的影响。HRT对总体死亡率的有益影响也是一个将被讨论的因素，并且在评估更年期女性HRT的利弊平衡时必须予以考虑。
