Zamarioli Ariane, Campbell Zachery R, Maupin Kevin A, Childress Paul J, Ximenez Joao P B, Adam Gremah, Chakraborty Nabarun, Gautam Aarti, Hammamieh Rasha, Kacena Melissa A
Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Orthopaedics and Anaesthesiology, Ribeirão Preto Medical School, Ribeirão Preto, SP, Brazil.
NPJ Microgravity. 2021 Mar 26;7(1):12. doi: 10.1038/s41526-021-00140-0.
With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J were divided into 4 groups: (1) Saline+Earth; (2) TPO + Earth; (3) Saline+Flight; and (4) TPO + Flight (n = 10/group). Saline- and TPO-treated mice underwent a femoral defect surgery, and 20 mice were housed in space ("Flight") and 20 mice on Earth for approximately 4 weeks. With the exception of the calvarium and incisor, positive changes were observed in TPO-treated, spaceflight bones, suggesting TPO may improve osteogenesis in the absence of mechanical loading. Thus, TPO, may serve as a new bone healing agent, and may also improve some skeletal properties of astronauts, which might be extrapolated for patients on Earth with restraint mobilization and/or are incapable of bearing weight on their bones.
随着人类在太空活动的增加，骨质流失和骨折将会发生。血小板生成素（TPO）是一种最近获得专利的骨愈合剂。在此，我们研究了TPO对遭受太空飞行并发生骨折的小鼠的全身影响。将40只9周龄的雄性C57BL/6 J小鼠分为4组：（1）生理盐水+地面组；（2）TPO+地面组；（3）生理盐水+飞行组；（4）TPO+飞行组（每组n = 10）。接受生理盐水和TPO治疗的小鼠进行了股骨缺损手术，20只小鼠被安置在太空（“飞行”组），20只小鼠在地球上饲养约4周。除颅骨和门牙外，在接受TPO治疗的太空飞行小鼠的骨骼中观察到了积极变化，这表明TPO可能在没有机械负荷的情况下改善骨生成。因此，TPO可能作为一种新的骨愈合剂，还可能改善宇航员的一些骨骼特性，这可能也适用于地球上需要限制活动和/或无法承重的患者。
