Nephrology Department, Centro Hospitalar e Universitário de Lisboa Central, Rua da Beneficência no. 8, 1050-099, Lisbon, Portugal.
Nova Medical School, Nova University, Lisbon, Portugal.
Calcif Tissue Int. 2021 Apr;108(4):528-538. doi: 10.1007/s00223-021-00838-z. Epub 2021 Mar 26.
A bone biopsy is still considered the gold standard for diagnosis of renal osteodystrophy. It allows to measure both static and dynamic parameters of bone remodeling and is the only method able to evaluate mineralization and allows analysis of both cortical and trabecular bone. Although bone volume can be measured indirectly by dual-energy X-ray absorptiometry, mineralization defects, bone metal deposits, cellular number/activity, and even turnover abnormalities are difficult to determine by techniques other than qualitative bone histomorphometry. In this review, we evaluate the role of bone biopsy in the clinical practice.
骨活检仍然被认为是诊断肾性骨营养不良的金标准。它可以测量骨重建的静态和动态参数，是唯一能够评估矿化并分析皮质骨和小梁骨的方法。尽管骨量可以通过双能 X 射线吸收法间接测量，但除了定性骨组织形态计量学之外，其他技术很难确定矿化缺陷、骨金属沉积、细胞数量/活性，甚至转换异常。在这篇综述中，我们评估了骨活检在临床实践中的作用。
