趋化因子 CCL3/CCR5 和 CX3CL1/CX3CR1 轴将 T 细胞导向人动脉粥样硬化斑块。
Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes.
机构信息
Laboratory of Atherothrombosis, Cardiology Department, Moscow State University of Medicine and Dentistry, Moscow, Russia.
Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
出版信息
Eur J Immunol. 2021 Jul;51(7):1857-1859. doi: 10.1002/eji.202049004. Epub 2021 Apr 15.
T-cell accumulation in atherosclerotic plaques contributes to plaque destabilization. We found that several chemokine receptors are differentially expressed on peripheral blood compared to plaque-resident T cells and corresponding ligands are upregulated in plaques. These data indicate that T-cell migration into human atherosclerotic plaques may predominantly occur via CCR5-CCL3 and CX3CR1-CX3CL1 interactions.
T 细胞在动脉粥样硬化斑块中的聚集导致斑块不稳定。我们发现，与斑块内驻留的 T 细胞相比，几种趋化因子受体在外周血中表达不同，相应的配体在斑块中上调。这些数据表明，T 细胞向人动脉粥样硬化斑块的迁移可能主要通过 CCR5-CCL3 和 CX3CR1-CX3CL1 相互作用发生。
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