急诊科用于癫痫持续状态的肌内注射咪达唑仑。

IM midazolam for status epilepticus in the emergency department.

作者信息

Mayhue F E

机构信息

Department of Surgery, University of Illinois College of Medicine, Peoria 61637.

出版信息

Ann Emerg Med. 1988 Jun;17(6):643-5. doi: 10.1016/s0196-0644(88)80408-6.

DOI:10.1016/s0196-0644(88)80408-6

PMID:3377295

Abstract

A 71-year-old man presented with a continuous generalized tonic-clonic seizure of 80 minutes duration. Multiple attempts to establish an IV line failed. Ten milligrams of midazolam hydrochloride was administered IM and was followed by prompt termination of seizure activity. This report discusses the pharmacokinetic and anticonvulsant properties of midazolam as an alternative to diazepam for the initial treatment of status epilepticus.

摘要

一名71岁男性出现持续80分钟的全身性强直阵挛性癫痫发作。多次尝试建立静脉通路均失败。给予10毫克盐酸咪达唑仑肌肉注射，随后癫痫活动迅速终止。本报告讨论了咪达唑仑作为地西泮替代药物用于癫痫持续状态初始治疗时的药代动力学和抗惊厥特性。