早产儿经自动控制吸入氧（FiO2）时脑和内脏氧合。
Cerebral and splanchnic oxygenation during automated control of inspired oxygen (FiO ) in preterm infants.
机构信息
Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.
Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.
出版信息
Pediatr Pulmonol. 2021 Jul;56(7):2067-2072. doi: 10.1002/ppul.25379. Epub 2021 Mar 26.
OBJECTIVES
Our aim in this study was to assess the effect of the Predictive Intelligent Control of Oxygenation (PRICO ) system on cerebral (rSO C) and splanchnic (rSO S) oxygenation in a cohort of preterm infants with frequent desaturations.
METHODS
Twenty infants with gestational age <32 weeks (n = 20) were assigned in random sequence to 12 h of automated or manual adjustment of FiO . Over this period, they were studied continuously by near-infrared spectroscopy (NIRS).
RESULTS
We found that rSO C [68.0% (60.5%-74.7%) vs. 68.5% (62%-72%); p = .824] and rSO S [27.0% (17.3%-45.7%) vs. 27.0% (15%-53%); p = .878] were similar during automatic and manual control of FiO . Time spent with SpO 90%-95% was higher during the automatic than manual control of FiO , while time spent with SpO <80% or >95% was lower.
CONCLUSIONS
Automated control of FiO with PRICO system did not improve brain and splanchnic oxygenation in comparison with manual control in a cohort of preterm infants, but it significantly decreased SpO fluctuations and limited the duration of both hypoxemia and hyperoxemia.
目的
本研究旨在评估氧合预测智能控制（PRICO）系统对伴有频繁血氧饱和度下降的早产儿脑（rSO₂C）和内脏（rSO₂S）氧合的影响。
方法
将 20 名胎龄<32 周的婴儿（n=20）随机分为自动或手动调整 FiO₂组，在此期间，他们通过近红外光谱（NIRS）连续监测。
结果
我们发现，在自动和手动 FiO₂控制下，rSO₂C[68.0%（60.5%-74.7%）与 68.5%（62%-72%）；p=0.824]和 rSO₂S[27.0%（17.3%-45.7%）与 27.0%（15%-53%）；p=0.878]相似。自动 FiO₂控制时 SpO₂90%-95%的时间高于手动控制，而 SpO₂<80%或>95%的时间较低。
结论
与手动控制相比，PRICO 系统自动控制 FiO₂并未改善早产儿脑和内脏氧合，但其显著降低了 SpO₂波动，并限制了低氧血症和高氧血症的持续时间。
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