Travers Colm P, Chahine Rouba, Nakhmani Arie, Aban Inmaculada, Carlo Waldemar A, Ambalavanan Namasivayam
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA.
Pediatr Res. 2025 Feb;97(3):1166-1170. doi: 10.1038/s41390-024-03460-5. Epub 2024 Aug 15.
Incubator oxygen may improve respiratory stability in preterm infants compared with nasal cannula oxygen.
Single center randomized trial of infants <29 weeks' gestation on supplemental oxygen at ≥32 weeks' postmenstrual age. Infants were crossed-over every 24 hours for 96 hours between incubator oxygen and nasal cannula ≤1.0 L/kg/min. We measured episodes of intermittent hypoxemia (oxygen saturations (SpO) < 85% ≥10 seconds), bradycardia, cerebral and abdominal hypoxemia, and end-tidal carbon dioxide.
We enrolled 25 infants with a gestational age of 26 weeks 4 days±15 days (mean ± SD) and birth weight 805 ± 202 grams. There were no differences in episodes of intermittent hypoxemia, bradycardia, or cerebral hypoxemia between groups. There were fewer episodes of abdominal hypoxemia <40% ≥10 seconds with incubator oxygen compared with nasal cannula (132 ± 130 versus 158 ± 125; p < 0.01). Time with SpO < 85% and abdominal hypoxemia was lower among infants on incubator oxygen. Carbon dioxide values were higher while on incubator oxygen (41 ± 11 versus 36 ± 10 mmHg; p < 0.02).
There was no difference in intermittent hypoxemia between incubator and nasal cannula oxygen among preterm infants on supplemental oxygen. Infants had higher levels of carbon dioxide while on incubator oxygen, which may have improved some measures of respiratory stability. CLINCALTRIALS.
NCT03333174 and NCT03174301.
In this randomized cross-over trial of preterm infants on supplemental oxygen, incubator oxygen did not decrease episodes of intermittent hypoxemia compared with nasal cannula oxygen. Incubator oxygen reduced time with oxygen saturations less than 85%, reduced abdominal hypoxemia, and increased carbon dioxide levels. Differences in measures of respiratory stability on incubator oxygen may be partly due to higher carbon dioxide levels compared with nasal cannula oxygen. The mode of supplemental oxygen administration may impact control of breathing in preterm infants through its effect on hypopharyngeal oxygen stability and carbon dioxide levels.
与鼻导管吸氧相比，暖箱吸氧可能会改善早产儿的呼吸稳定性。
对孕龄小于29周、孕龄≥32周且正在接受吸氧治疗的婴儿进行单中心随机试验。婴儿每24小时在暖箱吸氧和鼻导管吸氧（≤1.0 L/kg/min）之间交叉96小时。我们测量了间歇性低氧血症（血氧饱和度（SpO）<85%≥10秒）、心动过缓、脑和腹部低氧血症以及呼气末二氧化碳的发作情况。
我们纳入了25名婴儿，其孕龄为26周4天±15天（均值±标准差），出生体重为805±202克。两组之间在间歇性低氧血症、心动过缓或脑低氧血症的发作情况上没有差异。与鼻导管吸氧相比，暖箱吸氧时腹部低氧血症（<40%≥10秒）的发作次数更少（132±130次与158±125次；p<0.01）。暖箱吸氧的婴儿中，SpO<85%和腹部低氧血症的时间更短。暖箱吸氧时二氧化碳值更高（41±11 mmHg与36±10 mmHg；p<0.02）。
在接受吸氧治疗的早产儿中，暖箱吸氧和鼻导管吸氧在间歇性低氧血症方面没有差异。婴儿在暖箱吸氧时二氧化碳水平较高，这可能改善了一些呼吸稳定性指标。临床试验。
NCT03333174和NCT03174301。
在这项针对接受吸氧治疗的早产儿的随机交叉试验中，与鼻导管吸氧相比，暖箱吸氧并未减少间歇性低氧血症的发作次数。暖箱吸氧减少了血氧饱和度低于85%的时间，减少了腹部低氧血症，并提高了二氧化碳水平。暖箱吸氧时呼吸稳定性指标的差异可能部分归因于与鼻导管吸氧相比更高的二氧化碳水平。补充氧气的给药方式可能通过其对下咽氧气稳定性和二氧化碳水平的影响来影响早产儿的呼吸控制。
