Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, PR China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Ecotoxicol Environ Saf. 2021 Jun 1;215:112174. doi: 10.1016/j.ecoenv.2021.112174. Epub 2021 Mar 24.
Phthalates, which are used as excipients of drugs, have been related to adverse reproductive outcomes. However, the relationships between medication use and phthalate exposure among women undergoing in vitro fertilization (IVF) have not been studied.
To investigate the associations between the medication intake and phthalate metabolites in urine and follicular fluid (FF).
Eight phthalate metabolites were measured in urine and FF samples from 274 women undergoing IVF using liquid chromatography-tandem mass spectrometry. Information on recent medication intake was obtained via interview by trained staff. We constructed generalized linear regression models to examine the associations of medication intake with phthalate metabolite concentrations and dose-response relationships between the number of medicines used and metabolite concentrations in two matrices.
Four of 10 drugs were used by more than 10% of the participants, including vitamins (23.0%), traditional Chinese medicine (TCM, 22.3%), antioxidants (12.4%) and amoxicillin (10.2%). Participants who had used TCM had 26.0% (95% CI: 0.0, 58.8%), 32.6% (95% CI: 4.2, 68.8%) and 32.3% (95% CI: 2.6, 70.6%) higher urinary mono-n-butyl phthalate (MBP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) concentrations, respectively, than those who had not. Antioxidant intake was associated with a 30.6% (95% CI: -48.5, -6.6%) decrease in the urinary MBP concentration. Compared with non-users, women who reported the use of medicines had 53.2% (95% CI: 2.7, 128.5%) higher concentrations of MMP and a 37.7% (95% CI: -60.7, -1.5%) lower level of MBP in FF, respectively.
Our data suggest that the intake of some medications may increase phthalate exposure among women undergoing IVF.
作为药物辅料的邻苯二甲酸酯与不良生殖结局有关。然而，在接受体外受精（IVF）的女性中，药物使用与邻苯二甲酸酯暴露之间的关系尚未得到研究。
探讨药物摄入与尿液和卵泡液（FF）中邻苯二甲酸酯代谢物之间的关系。
使用液相色谱-串联质谱法对 274 名接受 IVF 的女性的尿液和 FF 样本中 8 种邻苯二甲酸酯代谢物进行了测量。通过经过培训的工作人员进行访谈获得最近药物摄入的信息。我们构建了广义线性回归模型，以检查药物摄入与邻苯二甲酸酯代谢物浓度之间的关系，并检查两种基质中使用药物数量与代谢物浓度之间的剂量反应关系。
10 种药物中有 4 种（23.0%）被超过 10%的参与者使用，包括维生素（23.0%）、中药（TCM，22.3%）、抗氧化剂（12.4%）和阿莫西林（10.2%）。使用 TCM 的参与者尿液中单正丁基邻苯二甲酸酯（MBP）、单（2-乙基-5-羟基己基）邻苯二甲酸酯（MEHHP）和单（2-乙基-5-氧代己基）邻苯二甲酸酯（MEOHP）浓度分别高出 26.0%（95%CI：0.0，58.8%）、32.6%（95%CI：4.2，68.8%）和 32.3%（95%CI：2.6，70.6%）。抗氧化剂摄入与尿液 MBP 浓度降低 30.6%（95%CI：-48.5，-6.6%）相关。与非使用者相比，报告使用药物的女性的 MMP 浓度分别高 53.2%（95%CI：2.7，128.5%），FF 中的 MBP 浓度分别低 37.7%（95%CI：-60.7，-1.5%）。
我们的数据表明，一些药物的摄入可能会增加接受 IVF 的女性的邻苯二甲酸酯暴露。
