Kiss I, Homonnay Z G, Mató T, Bányai K, Palya V
Scientific Support and Investigation Unit, Ceva-Phylaxia Ltd., H-1107 Budapest, Hungary.
Scientific Support and Investigation Unit, Ceva-Phylaxia Ltd., H-1107 Budapest, Hungary.
Poult Sci. 2021 May;100(5):101052. doi: 10.1016/j.psj.2021.101052. Epub 2021 Feb 16.
Fowl adenoviruses (FAdV), detected during routine diagnostic investigations from 38 countries (5 continents) over a decade, were partially sequenced and grouped by phylogenetic analysis. The partial polymerase gene nucleotide sequences of the 365 fowl adenovirus isolates resulted in the following species distribution: 11% FAdV-A; 3% FAdV-B; 2% FAdV-C; 34% FAdV-D; and 50% FAdV-E. Noticeably, only 79 of the detected strains could be associated with adenovirus-specific pathologic conditions: 62 (79%) with inclusion body hepatitis; 9 (11%) with gizzard erosion; and 8 (10%) with hepatitis hydropericardium syndrome. The remainder of the FAdV strains was detected as concomitant infection from other disease conditions almost exclusively in boilers of 27 to 42 d of age: the majority of them was FAdV-E followed by FAdV-D, and to a lesser extent of FAdV-A, B, and C, the latter ones have not been associated with any of the established adenovirus-caused syndromes in our collection. The highest ratio of coinfections was observed for FAdV-B (62%), while it was about 30% for the rest of the FAdV species. The most frequent coinfection, in connection with all FAdV species, was with the avian infectious bronchitis virus. The presented database will serve as the basis for comparative whole genome and cross-neutralization analysis of selected FAdV isolates.
在十年间，从38个国家（五大洲）的常规诊断调查中检测到的禽腺病毒（FAdV），经过部分测序并通过系统发育分析进行分组。365株禽腺病毒分离株的部分聚合酶基因核苷酸序列得出以下种类分布：11%为FAdV-A；3%为FAdV-B；2%为FAdV-C；34%为FAdV-D；50%为FAdV-E。值得注意的是，仅79株检测到的毒株可与腺病毒特异性病理状况相关：62株（79%）与包涵体肝炎相关；9株（11%）与肌胃糜烂相关；8株（10%）与心包积水肝炎综合征相关。其余的FAdV毒株几乎仅在27至42日龄的肉鸡中作为其他疾病状况的混合感染被检测到：其中大多数是FAdV-E，其次是FAdV-D，FAdV-A、B和C的比例较小，在我们收集的样本中，后几种尚未与任何已确定的腺病毒引起的综合征相关。FAdV-B的混合感染率最高（62%），而其他FAdV种类的混合感染率约为30%。与所有FAdV种类相关的最常见混合感染是与禽传染性支气管炎病毒。所呈现的数据库将作为所选FAdV分离株的全基因组比较和交叉中和分析的基础。
