Restoration of the sensitivity of Eimeria acervulina to anticoccidial drugs in the chicken following use of a live coccidiosis vaccine.

The efficacy of the anticoccidial drugs amprolium, clopidol, diclazuril, monensin, monensin + nicarbazin, narasin, narasin + nicarbazin, and salinomycin against field isolates of Eimeria acervulina obtained from a commercial broiler enterprise before and after immunization with a coccidiosis vaccine was investigated. Evaluated by weight gain, feed conversion, and lesion score following challenge, the isolate obtained before vaccination was resistant to all the drugs tested. By contrast, after vaccination the isolate was sensitive to all drugs evaluated by weight gain, and to most drugs judged by feed conversion and lesion score. It is concluded that vaccination had resulted in the restoration of sensitivity to these drugs.