KIAA1199 在癌症发生发展和治疗中的新兴作用
The emerging role of KIAA1199 in cancer development and therapy.
机构信息
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
出版信息
Biomed Pharmacother. 2021 Jun;138:111507. doi: 10.1016/j.biopha.2021.111507. Epub 2021 Mar 24.
KIAA1199, also known as CEMIP or HYBID, is an important member of the Human Unidentified Gene-Encoded (HUGE) database. Accumulated evidence has revealed that KIAA1199 is associated with tumor progression and metastasis in numerous malignancies, including colorectal, liver, gastric, pancreatic, breast, lung, prostate, ovarian and papillary thyroid cancers. As an oncogene, it plays crucial role in the proliferation, apoptosis, invasion and migration of various tumor cells. In addition, KIAA1199 is also involved in the regulation of multiple signal pathways such as epithelial-mesenchymal transition (EMT), Wnt/ β-catenin, MEK/ERK and PI3K/Akt. In this review, we summarized up to date advancement on the role of KIAA1199 in human cancer development, progression, and metastasis. We also addressed KIAA1199 as a potential therapeutic target for cancer therapy.
KIAA1199，又称为 CEMIP 或 HYBID，是人类未识别基因编码（HUGE）数据库的重要成员。越来越多的证据表明，KIAA1199 与包括结直肠癌、肝癌、胃癌、胰腺癌、乳腺癌、肺癌、前列腺癌、卵巢癌和甲状腺乳头状癌在内的多种恶性肿瘤的进展和转移有关。作为一种癌基因，它在多种肿瘤细胞的增殖、凋亡、侵袭和迁移中发挥着关键作用。此外，KIAA1199 还参与调节上皮-间充质转化（EMT）、Wnt/β-catenin、MEK/ERK 和 PI3K/Akt 等多种信号通路。本综述总结了 KIAA1199 在人类癌症发生、发展和转移中的作用的最新进展。我们还将 KIAA1199 作为癌症治疗的潜在治疗靶点进行了讨论。
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