偏头痛：疾病特征、生物标志物和精准医学。

Migraine: disease characterisation, biomarkers, and precision medicine.

机构信息

Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Danish Knowledge Center on Headache Disorders, Glostrup, Denmark; Department of Nervous Diseases of the Institute of Professional Education, IM Sechenov First Moscow State Medical University, Moscow, Russia; Department of Neurology, Azerbaijan Medical University, Baku, Azerbaijan.

Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.

出版信息

Lancet. 2021 Apr 17;397(10283):1496-1504. doi: 10.1016/S0140-6736(20)32162-0. Epub 2021 Mar 25.

DOI:10.1016/S0140-6736(20)32162-0

PMID:33773610

Abstract

Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria. A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine, including the underlying genetic and neurobiological factors. This complexity has generated momentum for biomarker research to improve disease characterisation and identify novel drug targets. In this Series paper, we present the progress that has been made in the search for biomarkers of migraine within genetics, provocation modelling, biochemistry, and neuroimaging research. Additionally, we outline challenges and future directions for each biomarker modality. We also discuss the advances made in combining and integrating data from multiple biomarker modalities. These efforts contribute to developing precision medicine that can be applied to future patients with migraine.

摘要

偏头痛是一种使人丧失能力的神经系统疾病，其诊断基于临床标准。这些标准的一个缺点是它们不能完全捕捉偏头痛的异质性，包括潜在的遗传和神经生物学因素。这种复杂性为生物标志物研究提供了动力，以改善疾病特征并确定新的药物靶点。在本系列论文中，我们介绍了在遗传学、激发模型、生物化学和神经影像学研究中寻找偏头痛生物标志物的进展。此外，我们概述了每种生物标志物模式的挑战和未来方向。我们还讨论了结合和整合来自多个生物标志物模式的数据所取得的进展。这些努力有助于开发可以应用于未来偏头痛患者的精准医学。