Stafford N D, Davies S J
Electron Microscopy UNit, Institute of Laryngology and Otology, London, England.
Ann Otol Rhinol Laryngol. 1988 May-Jun;97(3 Pt 1):302-7. doi: 10.1177/000348948809700319.
Scanning and transmission electron microscopy and light microscopy were used to study the distribution of squamous epithelium and ciliated respiratory type epithelium in ten midtrimester human fetal larynges. Particular attention was paid to the subglottic region, where previous studies have reported areas of squamous metaplasia in neonates, infants, and nonsmoking adults. Both types of epithelium were found in different proportions in the supraglottic, glottic, and subglottic regions. There was considerable downward extension of squamous epithelium from the glottis into the subglottic region, with a wide transition zone where both types of epithelium were found in close association. These observations would suggest that such areas of squamous epithelium in the nonglottic larynx are normal, rather than always indicating a response to extrinsic trauma or irritation. Therefore, the term squamous metaplasia may be inappropriate when applied to such areas in the adult larynx.
利用扫描电子显微镜、透射电子显微镜和光学显微镜，研究了10例孕中期人胎儿喉部鳞状上皮和纤毛呼吸型上皮的分布情况。特别关注了声门下区域，此前的研究报告称，新生儿、婴儿和不吸烟的成年人中存在该区域的鳞状化生。在声门上、声门和声门下区域均发现了不同比例的两种类型上皮。鳞状上皮从声门向下显著延伸至声门下区域，存在一个较宽的过渡带，两种类型上皮紧密相连。这些观察结果表明，非声门喉部的此类鳞状上皮区域是正常的，而非总是提示对外界创伤或刺激的反应。因此，将“鳞状化生”这一术语用于成人喉部的此类区域可能并不恰当。
