From the Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; School of Behavioural and Health Sciences, Australian Catholic University, Melbourne, Australia; Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
From the Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Am J Ophthalmol. 2021 Aug;228:16-26. doi: 10.1016/j.ajo.2021.03.021. Epub 2021 Mar 25.
To examine whether vision impairment and eye diseases are independently associated with memory decline in older adults.
Cohort study.
We included 8,315 participants aged 50-94 years in China Health and Retirement Longitudinal Study (CHARLS) from China and 8,939 participants aged 50-95 years in Health and Retirement Study (HRS) from the United States in our analysis.
During 4.0 years' follow-up, the composite memory decreased by 0.16 points in CHARLS. During 3.9 years' follow-up, the composite memory decreased by 0.51 in HRS. Distance vision impairment was inversely associated with an annual change in composite memory (β [95% CI]: -0.07 [-0.12, -0.01]) and immediate memory (-0.04 [-0.07, -0.02]) in CHARLS, and the corresponding values in HRS were -0.19 (-0.34, -0.05) and -0.07 (-0.13, -0.00), respectively. Near vision impairment was inversely associated with an annual change in delayed memory in CHARLS and composite memory, immediate memory, and delayed memory in HRS. In HRS, the association between distance vision impairment and memory decline was observed in individuals aged <65 years (β [95% CI]: -0.54 [-0.78, -0.30]) but not in those aged ≥65 years (-0.01 [-0.20, 0.18]). Cataract surgery or glaucoma was not significantly associated with memory decline in either CHARLS or HRS.
Distance vision impairment was independently associated with an accelerated rate of memory decline in both China and the United States. Near vision impairment was predictive of decline in delayed memory in China and of decline in composite, immediate, and delayed memory in the United States.
研究视力障碍和眼部疾病是否与老年人的记忆衰退独立相关。
队列研究。
我们在中国健康与退休纵向研究（CHARLS）中纳入了来自中国的 8315 名 50-94 岁的参与者和美国健康与退休研究（HRS）中的 8939 名 50-95 岁的参与者，对其进行了分析。
在 CHARLS 中，经过 4.0 年的随访，复合记忆下降了 0.16 分。在 HRS 中，经过 3.9 年的随访，复合记忆下降了 0.51 分。在 CHARLS 中，远距离视力障碍与复合记忆（β[95%可信区间]：-0.07[-0.12，-0.01]）和即时记忆（-0.04[-0.07，-0.02]）的年度变化呈负相关，HRS 中的对应值分别为-0.19（-0.34，-0.05）和-0.07（-0.13，-0.00）。近距离视力障碍与 CHARLS 中延迟记忆以及 HRS 中复合记忆、即时记忆和延迟记忆的年度变化呈负相关。在 HRS 中，远距离视力障碍与记忆衰退的关联仅见于年龄<65 岁的个体（β[95%可信区间]：-0.54[-0.78，-0.30]），而在年龄≥65 岁的个体中则不明显（-0.01[-0.20，0.18]）。白内障手术或青光眼在 CHARLS 和 HRS 中均与记忆衰退无显著关联。
远距离视力障碍与中国和美国的记忆衰退速度加快独立相关。近距离视力障碍预示着中国延迟记忆下降和美国复合、即时和延迟记忆下降。
