食物对氨比西林匹酯生物利用度的影响。
Influence of food on bioavailability of amdinocillin pivoxil.
作者信息
Bornemann L D, Castellano S, Lin A H, Enthoven D, Patel I H
机构信息
Pharmaceutical Research and Development, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
出版信息
Antimicrob Agents Chemother. 1988 Apr;32(4):592-4. doi: 10.1128/AAC.32.4.592.
Abstract
The bioavailability of amdinocillin was not altered when amdinocillin pivoxil was ingested 1 h before a standard breakfast, and it increased by 20% when amdinocillin pivoxil was ingested with or 1 h after a standard breakfast. Amdinocillin pivoxil would be convenient for patients since it may be taken with or without food.
摘要
在标准早餐前1小时服用匹氨西林时，匹氨西林的生物利用度未改变；在标准早餐时或早餐后1小时服用匹氨西林时，其生物利用度提高了20%。匹氨西林对患者来说很方便，因为它可以与食物同服或空腹服用。
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本文引用的文献
1
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J Antimicrob Chemother. 1982 Jan;9(1):7-27. doi: 10.1093/jac/9.1.7.
2
Gastroscopic and pharmacokinetic evaluation of a new pivmecillinam tablet.一种新的匹美西林片的胃镜检查及药代动力学评估
Eur J Clin Pharmacol. 1982;22(1):63-9. doi: 10.1007/BF00606427.
3
Pharmacokinetic studies with mecillinam and pivmecillinam.美西林和匹美西林的药代动力学研究。
Chemotherapy. 1975;21(3-4):146-66. doi: 10.1159/000221856.
4
Synergy of mecillinam, a beta-amidinopenicillanic acid derivative, combined with beta-lactam antibiotics.β-脒基青霉素酸衍生物美西林与β-内酰胺类抗生素的协同作用。
Antimicrob Agents Chemother. 1976 Sep;10(3):535-42. doi: 10.1128/AAC.10.3.535.
5
In vivo activity of the 6beta-amidinopenicillanic acid derivative, mecillinam, chemically linked or combined in varying ratios with 6-aminopenicillanic acid derivatives.6β-脒基青霉烷酸衍生物美西林与6-氨基青霉烷酸衍生物以不同比例化学连接或组合后的体内活性。
J Antimicrob Chemother. 1977 Jul;3 Suppl B:59-68. doi: 10.1093/jac/3.suppl_b.59.
6
How food and fluid affect drug absorption: results of initial studies.食物和液体如何影响药物吸收：初步研究结果
Postgrad Med. 1977 Jul;62(1):73-82. doi: 10.1080/00325481.1977.11712246.
7
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Arzneimittelforschung. 1978;28(10):1661-4.
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