Tybring L, Melchior N H
Antimicrob Agents Chemother. 1975 Sep;8(3):271-6. doi: 10.1128/AAC.8.3.271.
A newly described 6beta-amidinopenicillanic acid derivative, mecillinam (formerly called FL 1060), showed a high in vitro activity against Enterobacteriaceae. The effect on Escherichia coli was bactericidal and was due to lysis of the cells. The longer the culture grew under the influence of mecillinam or the lower the inoculum, the greater the bactericidal effect. The morphology of the cells changed towards large spheric forms (2 to 5 mum) under the influence of mecillinam. Consequently a great discrepancy between the optical density and the viable count was seen. The morphologically abnormal cells could be protected against lysis in vitro by addition of ionized compounds such as sodium chloride. Abnormal cells were more sensitive to ampicillin than normal cells. As expected synergy could be demonstrated between mecillinam and ampicillin. This was marked under experimental conditions where the abnormal cells were protected against lysis.
一种新描述的6β-脒基青霉烷酸衍生物美西林（以前称为FL 1060），对肠杆菌科细菌显示出高体外活性。对大肠杆菌的作用是杀菌性的，且是由于细胞裂解所致。在美西林影响下培养的时间越长或接种量越低，杀菌效果就越大。在美西林影响下，细胞形态朝着大的球形（2至5微米）变化。因此，在光密度和活菌数之间出现了很大差异。通过添加离子化合物如氯化钠，可在体外保护形态异常的细胞不发生裂解。异常细胞比正常细胞对氨苄西林更敏感。正如预期的那样，美西林和氨苄西林之间可显示协同作用。在保护异常细胞不发生裂解的实验条件下，这种协同作用很明显。
