Department of Clinical Pharmacy and Biopharmacy, University of Uyo, Uyo, Nigeria.
Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria.
Ir J Med Sci. 2022 Apr;191(2):885-894. doi: 10.1007/s11845-021-02599-y. Epub 2021 Mar 27.
The involvement of pharmacists in the provision of specialised care to patients with epilepsy is poor.
To evaluate the impact of pharmaceutical care services on the clinical outcomes of epilepsy.
Two selected major referral epilepsy treatment centres in southern Nigeria were used for the study. Patients were recruited from the Neurology and Medical out-patient clinics of the hospitals.
An open randomised controlled study was carried out on epilepsy patients receiving clinical care at the selected hospitals. Patients in the intervention group were offered pharmaceutical care services. The impact of the pharmaceutical care services on the clinical outcomes of epilepsy (seizure frequency and severity) was evaluated.
The effect of pharmaceutical care services on seizure frequency and severity in patients with epilepsy.
There was a statistically significant difference between the usual care (UC) and the pharmaceutical care (PC) group on the clinical outcomes of epilepsy post-PC intervention. Comparison between the groups (UC versus PC) revealed that patients in the PC group had a significantly lower seizure frequency score than those in the UC group at 3 months and 6 months-(pre-intervention: 3.09 versus 3.34; t = -1.685; p = 0.094) (3 months 2.45 versus 1.68; t = 4.494; p = 0.001), (6 months: 1.97 versus 0.92; t = -3.137; p = 0.001). Also, comparisons between the groups (UC versus PC) showed that patients in the PC group had a significantly lower seizure severity score than those in the UC group at 3 months and 6 months-(pre-intervention 18.46 versus 20.38; t = -3.102; p = 0.01) (3 months: 17.51 versus 14.79; t = 4.202; p = 0.001) (6 months 16.41 versus 11.66; t = 8.930; p = 0.001).
Pharmaceutical care interventions may significantly reduce seizure frequency and severity in patients with epilepsy.
These findings provide justification for the integration of pharmaceutical care services with other elements of health care for epilepsy patients.
药剂师在为癫痫患者提供专业护理方面的参与度较低。
评估药学服务对癫痫临床结局的影响。
在尼日利亚南部的两个选定的主要癫痫治疗转诊中心进行了这项研究。患者是从医院的神经科和内科门诊招募的。
对在选定医院接受临床护理的癫痫患者进行了一项开放随机对照研究。干预组患者提供药学服务。评估药学服务对癫痫（发作频率和严重程度）临床结局的影响。
药学服务对癫痫患者发作频率和严重程度的影响。
在药学服务干预后，常规护理（UC）组和药物治疗（PC）组在癫痫的临床结局方面存在统计学显著差异。两组之间的比较（UC 与 PC）显示，PC 组患者在 3 个月和 6 个月时的发作频率评分明显低于 UC 组（干预前：3.09 与 3.34；t=-1.685；p=0.094）（3 个月：2.45 与 1.68；t=4.494；p=0.001），（6 个月：1.97 与 0.92；t=-3.137；p=0.001）。此外，两组之间的比较（UC 与 PC）表明，PC 组患者的发作严重程度评分明显低于 UC 组，在 3 个月和 6 个月时（干预前：18.46 与 20.38；t=-3.102；p=0.01）（3 个月：17.51 与 14.79；t=4.202；p=0.001）（6 个月：16.41 与 11.66；t=8.930；p=0.001）。
药物治疗干预可能显著降低癫痫患者的发作频率和严重程度。
这些发现为将药物治疗服务与癫痫患者医疗保健的其他要素相结合提供了依据。
