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基于回归的方法来计算直线加速器锥形束 CT 成像设备的像素灵敏度图。

A regression-based approach to compute the pixels sensitivity map of linear accelerator portal imaging devices.

机构信息

Vanderbilt University Medical Center, Nashville, TN, 37212, USA.

Radiation Oncology Department, University of Virginia, Charlottesville, VA, 22908, USA.

出版信息

Med Phys. 2021 Aug;48(8):4598-4609. doi: 10.1002/mp.14862. Epub 2021 Jun 29.

Abstract

PURPOSE

To determine the pixel sensitivity map (PSM) for amorphous silicon electronic portal imaging devices (EPIDs) using a single flood field signal.

METHOD AND MATERIALS

A raw EPID signal results from the incident particle energy fluence, the inherent pixels response, and the background signal. In large open fields, particle energy fluence is a slow-varying signal that is locally considered spatially constant. Pixels response is a fast and abrupt varying behavior. The background signal is due to the EPID panel electronics, which is determined during radiation absence. To determine the PSM, after correcting for the background signal, we apply a model that captures the underlying smooth particle energy fluence-induced signal. This fluence signal-fitted model is then used to determine the PSM. Here, we use a polynomial-based regression surface model in both x and y dimensions. To validate the generated PSM, we measure beams and compute PSMs for multiple beam energies with and without flattening filters and for multiple source-to-imager distances. Since the PSM is a detector characteristic, it should be independent of those variables. We also intercompare measurements of fixed slit fields with the EPID being shifted between measurements.

RESULTS

The fluence signal of the flattening filter-free (FFF) beams was optimally modeled as a 12th degree polynomial surfaces, which had 0.1% residuals near the central axis. The 6 and 10 MV FFF PSMs were within ˜0.1%, and independent of the EPID SID, suggesting that the PSM is energy independent. The 6, 10, and 15 MV flattened-beam PSMs were well modeled as 12th degree polynomial surfaces, which were equivalent within ˜0.24% but differed from the FFF PSM by up to 0.5% near the beam central axis. Applying the FFF PSMs to the flattened-beam measurements reduced the central-axis deviation between the raw and corrected signal to 0.1%, confirming the PSM energy independence hypothesis. When the FFF PSM is utilized, output verification with shifted slit deliveries agreed within ˜0.5% for all beam energies, which is within the radiation delivery uncertainty of ˜0.57%.

CONCLUSION

PSM for MV EPIDs can be determined by separating out the slowly varying, well-behaved fluence signal from the pixel-to-pixel sensitivity variations. The quality of the PSM is found to be dependent on the quality of the surface fit, which is best for the 6 MV FFF beam measured at SID equal to 180 cm. Within fitting errors, the PSM is independent of beam energy for 6, 10, and 15 MV beams with and without flattening filters. The PSM generation does not require shifting the EPID panel nor multiple EPID panel irradiations and should be usable for linacs with fixed geometry EPIDs.

摘要

目的

使用单次漫射场信号确定非晶硅电子射野影像装置(EPID)的像素灵敏度图(PSM)。

方法与材料

原始 EPID 信号源自入射粒子能量通量、固有像素响应和背景信号。在大开放野中,粒子能量通量是一个缓慢变化的信号,在局部被认为是空间上恒定的。像素响应是一种快速而突然的变化行为。背景信号是由于 EPID 面板电子设备引起的,该信号在没有辐射时确定。为了确定 PSM,在对背景信号进行校正后,我们应用了一种模型,该模型捕获了潜在的平滑粒子能量通量诱导信号。然后使用该通量信号拟合模型来确定 PSM。在这里,我们在 x 和 y 方向上都使用基于多项式的回归曲面模型。为了验证生成的 PSM,我们测量了光束并为具有和不具有平坦化滤波器的多个光束能量以及多个源到成像器距离计算了 PSM。由于 PSM 是探测器特性,因此它应该与这些变量无关。我们还比较了在测量之间移动 EPID 时固定狭缝场的测量值和 EPID 的测量值。

结果

无平坦化滤波器(FFF)束的通量信号最佳地建模为 12 次多项式曲面,在中心轴附近有 0.1%的残差。6 和 10 MV 的 FFF PSM 相差约 ˜0.1%,与 EPID SID 无关,表明 PSM 与能量无关。6、10 和 15 MV 平坦化束 PSM 很好地建模为 12 次多项式曲面,在 ˜0.24%以内等效,但在光束中心轴附近与 FFF PSM 的差异最大可达 0.5%。将 FFF PSM 应用于平坦化束测量值将原始和校正信号之间的中心轴偏差降低到 0.1%,证实了 PSM 与能量无关的假设。当使用 FFF PSM 时,所有光束的偏移狭缝输送的输出验证都在 ˜0.5%以内,这在 ˜0.57%的辐射输送不确定性范围内。

结论

可以通过从像素到像素灵敏度变化中分离出缓慢变化的、表现良好的通量信号来确定 MV EPID 的 PSM。PSM 的质量取决于曲面拟合的质量,对于在 SID 等于 180 cm 处测量的 6 MV FFF 束,拟合质量最好。在拟合误差内,6、10 和 15 MV 束的 PSM 与能量无关,无论是否具有平坦化滤波器。PSM 的生成不需要移动 EPID 面板或多次 EPID 面板照射,并且应该可用于具有固定几何 EPID 的直线加速器。

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