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SS-31 通过减少细胞凋亡来保护视网膜色素上皮细胞免受 H2O2 诱导的细胞损伤。

SS-31 protect retinal pigment epithelial cells from H O -induced cell injury by reducing apoptosis.

机构信息

The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.

The First Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Clin Exp Pharmacol Physiol. 2021 Jul;48(7):1016-1023. doi: 10.1111/1440-1681.13484. Epub 2021 Mar 28.

DOI:10.1111/1440-1681.13484
PMID:33774859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8252508/
Abstract

Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells. Antioxidant supplementation is a plausible strategy to avoid oxidative stress and maintain the function of retina. d-Arg-2,6-dimethyltyrosine-Lys-Phe-NH2 (SS-31) has been used in the treatment of many diseases. In this study, we found that SS-31 attenuated hydrogen peroxide (H O )-induced loss of cell viability, reduced oxidative damage and cell apoptosis in RPE cells. HO-1, Trx-1 and Nrf-2 expression levels significantly increased on pre-treatment with SS-31 compared with the H O group. SS-31 inhibited apoptosis through the downregulation of Bax and the upregulation of Bcl-2. Our results suggest that SS-31 had a protective effect against H O treatment in ARPE-19 cells by enhancing the antioxidative enzymes expression and decreasing apoptosis, which could be considered a promising therapeutic intervention for retinal degeneration.

摘要

证据表明，氧化应激会导致视网膜或人视网膜色素上皮（RPE）细胞损伤。抗氧化剂补充是一种避免氧化应激和维持视网膜功能的合理策略。d-精氨酸-2,6-二甲基酪氨酸-Lys-Phe-NH2（SS-31）已被用于治疗许多疾病。在这项研究中，我们发现 SS-31 可减轻过氧化氢（H2O2）诱导的 RPE 细胞活力丧失，减少氧化损伤和细胞凋亡。与 H2O2组相比，SS-31 预处理可显著增加 HO-1、Trx-1 和 Nrf-2 的表达水平。SS-31 通过下调 Bax 和上调 Bcl-2 抑制细胞凋亡。我们的结果表明，SS-31 通过增强抗氧化酶的表达和减少细胞凋亡对 ARPE-19 细胞的 H2O2处理具有保护作用，这可能被认为是治疗视网膜变性的一种有前途的治疗干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1db/8252508/b36e3ddf6d20/CEP-48-1016-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1db/8252508/5424bc92c822/CEP-48-1016-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1db/8252508/918ec1bbe03e/CEP-48-1016-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1db/8252508/b36e3ddf6d20/CEP-48-1016-g005.jpg

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