绝经后妇女血脂异常与骨质疏松症的关系。
Association of dyslipidaemia with osteoporosis in postmenopausal women.
机构信息
Department of Vasculocardiology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
J Int Med Res. 2021 Mar;49(3):300060521999555. doi: 10.1177/0300060521999555.
OBJECTIVE
To assess the association of dyslipidaemia with osteoporosis in postmenopausal women.
METHODS
Data from 160 postmenopausal women with newly diagnosed osteoporosis (osteoporosis group) and 156 healthy controls (control group) were retrospectively reviewed from 2016 to 2020. The primary outcomes were laboratory values assessed by a multivariate binary logistic regression model.
RESULTS
Factors that greatly increased the risk of being in the osteoporosis group included high low-density lipoprotein (LDL) and low high-density lipoprotein (HDL) levels. The osteoporosis group had lower HDL and higher LDL levels than the control group. A multivariate binary logistic regression model showed that lower HDL and higher LDL levels were the only variables that were significantly associated with osteoporosis (odds ratio 1.86, 95% confidence interval: 3.66-4.25 and odds ratio 1.47, 95% confidence interval: 1.25-2.74, respectively).
CONCLUSION
Low HDL and high LDL levels may be associated with the occurrence of osteoporosis in postmenopausal women.
目的
评估血脂异常与绝经后妇女骨质疏松症的关系。
方法
回顾性分析 2016 年至 2020 年期间 160 例新诊断骨质疏松症（骨质疏松组）和 156 例健康对照者（对照组）的数据。主要结局是通过多变量二项逻辑回归模型评估的实验室值。
结果
大大增加发生骨质疏松症风险的因素包括低密度脂蛋白（LDL）升高和高密度脂蛋白（HDL）降低。骨质疏松组的 HDL 水平低于对照组，而 LDL 水平高于对照组。多变量二项逻辑回归模型显示，较低的 HDL 和较高的 LDL 水平是与骨质疏松症显著相关的唯一变量（比值比 1.86，95%置信区间：3.66-4.25 和比值比 1.47，95%置信区间：1.25-2.74）。
结论
低 HDL 和高 LDL 水平可能与绝经后妇女骨质疏松症的发生有关。
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