术后控制营养状况（CONUT）评分在多形性胶质母细胞瘤中的临床意义。

Clinical significance of postoperatif controlling nutritional status (CONUT) score in glioblastoma multiforme.

机构信息

Department of Medical Oncology, Adnan Menders University Faculty of Medicine, Aydın, Turkey.

出版信息

J Clin Neurosci. 2021 Apr;86:260-266. doi: 10.1016/j.jocn.2021.01.036. Epub 2021 Feb 19.

DOI:10.1016/j.jocn.2021.01.036

PMID:33775339

Abstract

PURPOSE

The Controlling Nutritional Status (CONUT) Score, a new parameter that reflects the immuno-nutritional status, has been closely associated with prognosis in many cancer types. However, the prognostic significance of the CONUT score in Glioblastoma Multiforme (GBM) is not known. In this study, we aimed to show the prognostic significance of the CONUT score in the postoperative period in patients with GBM.

METHODS

120 patients followed up with GBM were included in the study, retrospectively. According to the receiver operating characteristic (ROC) curve analysis, the optimal cut-off values were determined for the CONUT score, and the patients were divided into low (<2.5) and high (≥2.5) CONUT groups. Systemic immune inflammation index (SII), prognostic nutritional index (PNI), and neutrophil-lymphocyte ratio (NLR) were grouped according to the cut-off point of 1111, 46.5, and 4.48, respectively. Cox regression analyzes were used to assess their prognostic significance for progression-free survival (PFS) and overall survival (OS).

RESULTS

The high CONUT score group was found to have worse PFS and OS than the low CONUT score group (p < 0.001, p < 0.001). In univariate analysis, age, gender, comorbidity, CONUT score, SII, PNI, NLR were found to be significant for both PFS and OS. In multivariate analysis, only age and CONUT score were found as independent prognostic factors for both PFS (p: 0.040, p < 0,001) and OS (p: 0,041, p < 0,001).

CONCLUSION

The CONUT score in the postoperative period in patients with GBM is an independent prognostic parameter that predicts progression and survival.

摘要

目的

控制营养状况（CONUT）评分是一种反映免疫营养状况的新参数，与许多癌症类型的预后密切相关。然而，CONUT 评分在多形性胶质母细胞瘤（GBM）中的预后意义尚不清楚。在本研究中，我们旨在显示 CONUT 评分在 GBM 患者术后期间的预后意义。

方法

回顾性纳入 120 例接受 GBM 随访的患者。根据受试者工作特征（ROC）曲线分析，确定 CONUT 评分的最佳截断值，并将患者分为低（<2.5）和高（≥2.5）CONUT 组。根据 1111、46.5 和 4.48 的截断值，将全身免疫炎症指数（SII）、预后营养指数（PNI）和中性粒细胞-淋巴细胞比值（NLR）分组。Cox 回归分析用于评估它们对无进展生存期（PFS）和总生存期（OS）的预后意义。

结果

高 CONUT 评分组的 PFS 和 OS 均较低 CONUT 评分组差（p<0.001，p<0.001）。在单因素分析中，年龄、性别、合并症、CONUT 评分、SII、PNI、NLR 对 PFS 和 OS 均有显著影响。在多因素分析中，仅年龄和 CONUT 评分被认为是 PFS（p：0.040，p<0.001）和 OS（p：0.041，p<0.001）的独立预后因素。