胶质母细胞瘤患者预后营养指数评分和控制营养状况评分的预后价值：一项综合荟萃分析。
Prognostic value of prognostic nutritional index score and controlling nutritional status score in patients with glioblastoma: A comprehensive meta-analysis.
作者信息
Peng Jie, Li Xiaoyu, Huang Mingsheng, Ma Mincai, Huang Qin, Huang Ning, Cheng Yuan
机构信息
Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hepatology Department, Chongqing Hospital of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Chongqing, China.
出版信息
Front Oncol. 2023 Feb 16;13:1117764. doi: 10.3389/fonc.2023.1117764. eCollection 2023.
INTRODUCTION
Several nutritional indicators, including the prognostic nutritional index (PNI) score and the controlling nutritional status (CONUT) score, have been shown to predict the prognosis of patients with glioblastoma. The present meta-analysis was performed to further evaluate the prognostic value of PNI and CONUT scores in patients with glioblastoma.
METHOD
The PubMed, EMBASE and Web of Science databases were comprehensively searched for studies that evaluated the ability of PNI and CONUT scores to predict the prognosis of patients with glioblastoma. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated by univariate and multivariate analyses.
RESULT
Ten articles were included in this meta-analysis, involving 1406 patients with glioblastoma. Univariate analyses showed that a high PNI score was predictive of greater overall survival (OS; HR 0.50; 95% CI, 0.43, 0.58; I 0%) and progression free survival (PFS; HR 0.63; 95% CI, 0.50, 0.79; I 0%), whereas a low CONUT score predictive of longer OS (HR 2.39; 95% CI, 1.77, 3.23; I 25%). Multivariate analyses showed that high PNI score (HR 0.64; 95% CI, 0.49, 0.84; I 24%) and low CONUT score (HR 2.79; 95% CI, 2.01, 3.89; I 39%) were independently associated with longer OS, whereas PNI score was not significantly associated with PFS (HR 1.02; 95% CI, 0.65, 1.59; I 0%).
CONCLUSION
PNI scores and CONUT scores have prognostic value in patients with glioblastoma. Additional large-scale studies, however, are required to confirm these results.
引言
包括预后营养指数（PNI）评分和控制营养状况（CONUT）评分在内的多项营养指标已被证明可预测胶质母细胞瘤患者的预后。本荟萃分析旨在进一步评估PNI和CONUT评分在胶质母细胞瘤患者中的预后价值。
方法
全面检索PubMed、EMBASE和Web of Science数据库，以查找评估PNI和CONUT评分预测胶质母细胞瘤患者预后能力的研究。通过单因素和多因素分析计算风险比（HR）和95%置信区间（CI）。
结果
本荟萃分析纳入了10篇文章，涉及1406例胶质母细胞瘤患者。单因素分析显示，高PNI评分预示着更长的总生存期（OS；HR 0.50；95%CI，0.43，0.58；I² 0%）和无进展生存期（PFS；HR 0.63；95%CI，0.50，0.79；I² 0%），而低CONUT评分预示着更长的OS（HR 2.39；95%CI，1.77，3.23；I² 25%）。多因素分析显示，高PNI评分（HR 0.64；95%CI，0.49，0.84；I² 24%）和低CONUT评分（HR 2.79；95%CI，2.01，3.89；I² 39%）与更长的OS独立相关，而PNI评分与PFS无显著相关性（HR 1.02；95%CI，0.65，1.59；I² 0%）。
结论
PNI评分和CONUT评分在胶质母细胞瘤患者中具有预后价值。然而，需要更多大规模研究来证实这些结果。
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