Department of Medicine, Women's College Research Institute, University of Toronto, 6307 - 76 Grenville Street, 6th Floor, Toronto, Ontario M5S 1B2, Canada.
Université de Lorraine, EA 4360 APEMAC, Nancy, France.
Semin Arthritis Rheum. 2021 Jun;51(3):618-622. doi: 10.1016/j.semarthrit.2021.03.010. Epub 2021 Mar 20.
Towards developing an instrument to measure knee and hip osteoarthritis (KHOA) flare, the Outcome Measures in Rheumatology (OMERACT) Flares in OA Working Group first sought to identify and define relevant domains of flare in KHOA.
Guided by OMERACT Filter 2.1, candidate domains were identified from data generated in interviews, in English or French, with persons with KHOA and health professionals (HPs) who treat OA. The first and second rounds of an online Delphi process with patients and HPs, including researchers, selected relevant domains. The third round provided agreement on the selected domains and their definitions. At the virtual OMERACT 2020 workshop, the proposed domains and their definitions were discussed in facilitated breakout groups with patients and HPs. Participants then voted, with consensus set at ≥70%.
Qualitative interviews characterizing OA flare were completed with 29 persons with KHOA and 16 HPs. Content was analyzed and grouped into nine clusters. These candidate domains were included in two Delphi rounds, completed by 91 patients and 165 HPs then 50 patients and 116 HPs, per round, respectively. This resulted in selecting five relevant domains. A final Delphi round, completed by 38 patients and 89 HPs, provided agreement on these domains and their definitions. The OMERACT virtual vote included 27 patients and 106 HPs. The domains and their definitions were endorsed with ≥98% agreement. Domains include: Pain, Swelling, Stiffness, Psychological aspects, and Impact of symptoms, all defined "during flare".
Using OMERACT methodology, we have developed five domains of KHOA flare that were highly endorsed by patients and HPs.
为了开发一种测量膝关节和髋关节骨关节炎（KHOA）发作的工具，风湿病结局测量（OMERACT）发作工作组首先试图确定和定义 KHOA 发作中的相关领域。
在 OMERACT 过滤器 2.1 的指导下，从对患有 KHOA 和治疗 OA 的健康专业人员（HPs）的访谈中以英语或法语生成的数据中确定候选领域。患者和 HPs（包括研究人员）的在线 Delphi 过程的第一和第二轮选择了相关领域。第三轮就选定的领域及其定义达成一致。在虚拟的 OMERACT 2020 研讨会上，与患者和 HPs 一起的小组讨论了拟议的领域及其定义。参与者随后进行了投票，共识设定为≥70%。
对 29 名患有 KHOA 和 16 名 HPs 进行了定性访谈，以描述 OA 发作。对内容进行了分析并分为九个聚类。这些候选领域包括在两轮 Delphi 中，每轮分别有 91 名患者和 165 名 HPs 以及 50 名患者和 116 名 HPs 完成。这导致选择了五个相关领域。最后一轮 Delphi 由 38 名患者和 89 名 HPs 完成，对这些领域及其定义达成了一致。OMERACT 虚拟投票包括 27 名患者和 106 名 HPs。领域及其定义的认可度≥98%。领域包括：疼痛、肿胀、僵硬、心理方面和症状的影响，均在“发作期间”定义。
使用 OMERACT 方法，我们已经开发出五个 KHOA 发作领域，得到了患者和 HPs 的高度认可。
