Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
J Pharm Sci. 2021 Jul;110(7):2625-2628. doi: 10.1016/j.xphs.2021.03.019. Epub 2021 Mar 26.
Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.
连续制造是未来制造解决方案的重要组成部分，能够实现产品高质量和简化开发流程。计算机模拟的可能性不断增加，为连续制造应用创新的混合原理提供了可能。然而，这些基于模拟的创新理念需要实验验证。基于增材制造的快速原型制作为低成本评估这些理念提供了可能性。在这项研究中，使用增材制造制造了一种新型的粉末混合几何形状，并进一步与在线近红外光谱仪接口，以研究该几何形状中的停留时间分布（RTD）。
