Hong Lv, Hongmei Wang, Leijie Xie, Dandan Zou, Peng Liu, Zhifei Hu, Ruimin Ma, Yijun Shi, Guanghui Zheng, Guojun Zhang
Clinical Diagnosis Department of Beijing Tiantan Hospital & Capital Medical University, China; NMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Fengtai district, Beijing, 100076, China; Beijing Engineering Research Center of Immunological Reagents Clinical Research, Fengtai district, Beijing, 100076, China.
Clinical Diagnosis Department of Beijing Rehabilitation Hospital & Capital Medical University, China.
Clin Chim Acta. 2021 Jul;518:110-115. doi: 10.1016/j.cca.2021.03.014. Epub 2021 Mar 26.
The present study aims to correlate the severity of post-stroke depression (PSD) and serum ceramide concentration.
In this two-center case-control study, we prospectively collected clinical and demographical information from age and gender-matched 51 PSD patients, 56 non-post-stroke depression (Non-PSD) patients, and 39 patients with major depression (MD) to perform the suitable biochemical analysis to bring a correlation in causing depression in patients soon after the stroke. The ROC curve method was used to evaluate ceramide's diagnostic efficacy in all three groups of patients. A follow-up analysis was also conducted based on PSD severity to associate serum ceramide levels and neuropsychiatric symptoms. The severity of the patient's depressive symptoms was assessed by using the self-rating depression scale (SDS).
In comparison between PSD and MD patients, three serum ceramide species were found to be significantly different. Compared with Non-PSD patients, PSD patients had significantly higher levels of all the four serum ceramides, and increasing levels ofC16:0, C18:0(VS MD) and C16: 0(VS Non-PSD) serve as a diagnostic tool and an independent risk factor in all three categories of patients. Moreover, the follow-up analysis results showed that, as the treatment progressed, the differences in the 3 serum ceramide species were statistically significant.
There was a stage-specific association between serum ceramides and PSD, and the potential pathophysiological mechanism has to be investigated in future research.
本研究旨在关联中风后抑郁症（PSD）的严重程度与血清神经酰胺浓度。
在这项双中心病例对照研究中，我们前瞻性地收集了年龄和性别匹配的51例PSD患者、56例非中风后抑郁症（Non-PSD）患者和39例重度抑郁症（MD）患者的临床和人口统计学信息，以进行合适的生化分析，从而找出中风后不久导致患者抑郁的相关性。采用ROC曲线法评估神经酰胺在所有三组患者中的诊断效能。还基于PSD严重程度进行了随访分析，以关联血清神经酰胺水平和神经精神症状。采用自评抑郁量表（SDS）评估患者抑郁症状的严重程度。
在PSD患者与MD患者的比较中，发现三种血清神经酰胺种类存在显著差异。与Non-PSD患者相比，PSD患者的所有四种血清神经酰胺水平均显著更高，且C16:0、C18:0（与MD相比）和C16:0（与Non-PSD相比）水平的升高可作为所有三类患者的诊断工具和独立危险因素。此外，随访分析结果显示，随着治疗进展，三种血清神经酰胺种类的差异具有统计学意义。
血清神经酰胺与PSD之间存在阶段特异性关联，其潜在的病理生理机制有待未来研究进一步探究。
