UK Field Epidemiology Training Programme (FETP), Public Health England, London, United Kingdom; Field Service, Midlands, National Infection Service, Public Health England, Birmingham, United Kingdom.
Warwick Medical School, University of Warwick, Warwick, United Kingdom.
J Infect. 2021 May;82(5):151-161. doi: 10.1016/j.jinf.2021.03.019. Epub 2021 Mar 26.
Screening for SARS-CoV-2 antibodies is under way in some key worker groups; how this adds to self-reported COVID-19 illness is unclear. In this study, we investigate the association between self-reported belief of COVID-19 illness and seropositivity.
Cross-sectional study of three key worker streams comprising (A) Police and Fire & Rescue (2 sites) (B) healthcare workers (1 site) and (C) healthcare workers with previously positive PCR result (5 sites). We collected self-reported signs and symptoms of COVID-19 and compared this with serology results from two SARS-CoV-2 immunoassays (Roche Elecsys® and EUROIMMUN).
Between 01 and 26 June, we recruited 2847 individuals (Stream A: 1,247, Stream B: 1,546 and Stream C: 154). Amongst those without previous positive PCR tests, 687/2,579 (26%) reported belief they had COVID-19, having experienced compatible symptoms; however, only 208 (30.3%) of these were seropositive on both immunoassays. Both immunoassays had high sensitivities relative to previous PCR positivity (>93%); there was also limited decline in antibody titres up to 110 days post symptom onset. Symptomatic but seronegative individuals had differing symptom profiles and shorter illnesses than seropositive individuals.
Non-COVID-19 respiratory illness may have been mistaken for COVID-19 during the outbreak; laboratory testing is more specific than self-reported key worker beliefs in ascertaining past COVID-19 disease.
目前正在一些关键工作人群中进行 SARS-CoV-2 抗体筛查；但尚不清楚这对自我报告的 COVID-19 疾病有何影响。在这项研究中，我们调查了自我报告的 COVID-19 疾病信念与血清阳性之间的关联。
横断面研究了三个关键工作人群，包括（A）警察和消防与救援（2 个地点）（B）医护人员（1 个地点）和（C）有先前 SARS-CoV-2 PCR 阳性结果的医护人员（5 个地点）。我们收集了自我报告的 COVID-19 症状和体征，并将其与来自两种 SARS-CoV-2 免疫分析（罗氏 Elecsys®和 EUROIMMUN）的血清学结果进行了比较。
在 6 月 1 日至 26 日期间，我们招募了 2847 名个体（A 组：1247 名，B 组：1546 名，C 组：154 名）。在没有先前阳性 PCR 检测结果的人群中，有 687/2579（26%）报告称他们有 COVID-19 疾病信念，经历过符合的症状；但只有 208（30.3%）人在两种免疫分析中均呈血清阳性。两种免疫分析的相对先前 PCR 阳性的敏感性均较高（>93%）；在症状出现后 110 天内，抗体滴度也有有限下降。有症状但血清阴性的个体与血清阳性的个体相比，有不同的症状谱和较短的疾病持续时间。
在疫情期间，非 COVID-19 呼吸道疾病可能被误认为是 COVID-19；与自我报告的关键工作者信念相比，实验室检测在确定过去的 COVID-19 疾病方面更具特异性。
