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作者信息
Fesser Anna, Kaiser Marcel, Mäser Pascal
机构信息
Universität Basel Schweizerisches Tropen- und Public Health-Institut (Swiss TPH), Socinstraße 57, CH-4051 Basel, Schweiz.
出版信息
Biospektrum (Heidelb). 2021;27(2):168-170. doi: 10.1007/s12268-021-1554-z. Epub 2021 Mar 23.
Abstract
Chagas disease is a zoonosis caused by and transmitted by triatomine bugs. Autochthonous to Latin America, Chagas disease has spread globally through travel and migration. New drugs are needed urgently, in particular drugs that cure the chronic stage. This is where high-content imaging makes a key contribution: assays with fluorescent parasites in cell culture allow to determine pharmacodynamic parameters and to better assess the antichagasic potential of new molecules.
摘要
恰加斯病是一种由锥蝽传播的人畜共患病。恰加斯病原产于拉丁美洲，已通过旅行和移民传播到全球。迫切需要新药，尤其是能治愈慢性阶段的药物。这正是高内涵成像发挥关键作用之处：在细胞培养中对荧光寄生虫进行检测，有助于确定药效学参数，并更好地评估新分子的抗恰加斯病潜力。
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