Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco.
Faculty of Sciences of Tetouan, Abdelmalek Essaadi University, Tetouan, Morocco.
Mediators Inflamm. 2021 Mar 11;2021:8847557. doi: 10.1155/2021/8847557. eCollection 2021.
Systemic lupus erythematosus (SLE) is a complex autoimmune inflammatory disease characterized by an unknown etiology and a highly variable clinical presentation. This clinical heterogeneity might be explained by dysregulation of tolerance to self and apoptotic mechanisms, overproduction of autoantibodies, and abnormal cytokine levels. Cytokine imbalance levels have been associated with disease activity and severity in SLE patients. In the last years, salivary cytokines related to SLE have gained significant attention and researchers have begun to focus on the identification of cytokines in the saliva of SLE patients using it as a diagnostic fluid for the inflammatory process underlying SLE. This review highlights and summarizes recent studies revealing the cytokines that have been identified in the saliva of individuals with SLE. Data reported and discussed in this report may provide useful additional information to better understand the mechanisms associated with the disease.
系统性红斑狼疮（SLE）是一种复杂的自身免疫性炎症性疾病，其病因不明，临床表现多样。这种临床异质性可能与对自身的耐受性失调和凋亡机制、自身抗体的过度产生以及异常的细胞因子水平有关。细胞因子失衡水平与 SLE 患者的疾病活动度和严重程度相关。近年来，与 SLE 相关的唾液细胞因子引起了人们的极大关注，研究人员开始关注使用 SLE 患者的唾液来识别细胞因子，将其作为 SLE 潜在炎症过程的诊断液。本综述重点介绍并总结了最近的研究，揭示了在 SLE 患者唾液中发现的细胞因子。本报告中报告和讨论的数据可能提供有用的补充信息，以帮助更好地了解与疾病相关的机制。
