Wick M R, Stanley S J, Swanson P E
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis.
Arch Pathol Lab Med. 1988 Jun;112(6):616-20.
The efficacy of two new monoclonal antibodies with cell lineage-restricted reactivity (HMB-45 [melanocytes] and anti-synaptophysin [neuroepithelial cells]) was compared with that of "traditional" antibody panels in the delineation of malignant melanoma (MM) of the sinonasal region, nasopharyngeal carcinoma (NPC), and olfactory neuroblastoma (ONBL). HMB-45 recognized all of eight melanomas and stained one of five neuroblastomas, but failed to label any of 12 cases of NPC. All examples of ONBL were stained by anti-synaptophysin; other tumors were nonreactive with this reagent. A panel of antibodies to cytokeratin, vimentin, epithelial membrane antigen, and S100 protein was also effective in discriminating between MM, NPC and ONBL. These results suggest that HMB-45 and anti-synaptophysin are comparable in utility to more extended antibody panels in the diagnosis of sinonasal malignancies, but only if used in combination with one another.
将两种具有细胞谱系限制性反应性的新型单克隆抗体（HMB - 45[黑色素细胞]和抗突触素[神经上皮细胞]）与“传统”抗体组合在鼻窦区域恶性黑色素瘤（MM）、鼻咽癌（NPC）和嗅神经母细胞瘤（ONBL）的诊断中的效果进行了比较。HMB - 45识别出所有8例黑色素瘤，对5例神经母细胞瘤中的1例进行了染色，但未标记12例NPC中的任何一例。所有ONBL病例均被抗突触素染色；其他肿瘤对该试剂无反应。一组针对细胞角蛋白、波形蛋白、上皮膜抗原和S100蛋白的抗体在区分MM、NPC和ONBL方面也有效。这些结果表明，在鼻窦恶性肿瘤的诊断中，HMB - 45和抗突触素在实用性上与更广泛的抗体组合相当，但前提是两者联合使用。
