Yakobson Alexander, Alguayn Wafeek, Shalata Walid, Levin Daniel, Kian Tawfeek A, Korngreen Amir, Gibbs Rachel, Salah Mahmuod A, Benzion Samueli, Lavrenkov Konstantin, Roisman Laila C, Dudnik Yulia, Peled Nir, Refaely Yael, Kian Waleed
The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel.
Department of Cardiac Surgery, Soroka Medical Center, Beer-Sheva, Israel.
Case Rep Oncol. 2021 Mar 3;14(1):309-317. doi: 10.1159/000510806. eCollection 2021 Jan-Apr.
Epithelioid hemangioma (EH) and epithelioid hemangioendothelioma (EHE) are both rare vascular tumors. EH tumors are often benign while EHE tumors have moderate malignant potential. Here, we present three unique cases at Soroka Medical Center, two featuring EH of the bone and one presenting EHE of the mediastinum. Each case demonstrates distinct treatment challenges due to the rarity of both diseases and lack of established guidelines. We propose three treatment approaches including pazopanib for salvage therapy of EH of the bone and minimally invasive surgical resection which in these cases lead to complete symptom relief and tumor stabilization upheld over time with close follow-up.
上皮样血管瘤（EH）和上皮样血管内皮瘤（EHE）均为罕见的血管肿瘤。EH肿瘤通常为良性，而EHE肿瘤具有中等恶性潜能。在此，我们展示索罗卡医疗中心的三例独特病例，其中两例为骨EH，一例为纵隔EHE。由于这两种疾病均罕见且缺乏既定指南，每例病例都呈现出独特的治疗挑战。我们提出三种治疗方法，包括使用帕唑帕尼对骨EH进行挽救治疗以及微创外科切除，在这些病例中，这些方法可带来完全的症状缓解和肿瘤稳定，通过密切随访可长期维持。
