Dai Xiaofeng, Wang Danjun, Zhang Jianying
Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
BGI College & Henan Institute of Medical and Pharmaceutical Sciences in Academy of Medical Science, Zhengzhou University, Zhengzhou, China.
Apoptosis. 2021 Aug;26(7-8):385-414. doi: 10.1007/s10495-021-01682-0. Epub 2021 Jul 8.
Cancer cells are disordered by nature and thus featured by higher internal redox level than healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain threshold, rendering therapeutic strategies relying on redox control a possible cancer management solution. Yet, various programmed cell death events have been consecutively discovered, complicating our understandings on their associations with redox imbalance and clinical implications especially therapeutic design. Thus, it is imperative to understand differences and similarities among programmed cell death events regarding their associations with redox imbalance for improved control over these events in malignant cells as well as appropriate design on therapeutic approaches relying on redox control. This review addresses these issues and concludes by bringing affront cold atmospheric plasma as an emerging redox controller with translational potential in clinics.
癌细胞本质上是无序的，因此其内部氧化还原水平高于健康细胞。如果超过一定阈值，氧化还原失衡可能引发程序性细胞死亡，这使得依赖氧化还原控制的治疗策略成为一种可能的癌症管理解决方案。然而，各种程序性细胞死亡事件相继被发现，这使我们对它们与氧化还原失衡的关联以及临床意义（尤其是治疗设计）的理解变得复杂。因此，必须了解程序性细胞死亡事件之间在与氧化还原失衡关联方面的异同，以便更好地控制恶性细胞中的这些事件，并合理设计依赖氧化还原控制的治疗方法。本综述探讨了这些问题，并最终提出冷大气等离子体作为一种新兴的氧化还原控制器，在临床上具有转化潜力。
