Al-Gahmi Aboelkhair, Alhuthali Mohammed, Alrehaili Mohammad, Baltow Badee, Tashkandi Emad
Department of Medical Oncology, Oncology Center, King Abdullah Medical City, Makkah, Saudi Arabia.
College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Case Rep Oncol. 2021 Mar 8;14(1):352-364. doi: 10.1159/000514147. eCollection 2021 Jan-Apr.
The incidence of synchronous multiple primary malignancies (MPMs), which include both solid and hematological malignancy, is considered very rare. In addition, the involvement of sites such as brain, thyroid, and breast are among the least reported in such complex conditions. Here we report five different types of solid tumors including glioblastoma multiforme, thyroid papillary carcinoma, breast invasive ductal carcinoma, colon cancer, and gastric adenocarcinoma that were associated with synchronous five different hematological malignancies in the form of T-cell lymphoblastic non-Hodgkin lymphoma (NHL), nodal marginal zone NHL, diffuse large B-cell NHL, Hodgkin lymphoma, and gastric mucosa-associated lymphoid tissue marginal zone NHL, respectively. The diagnosis of MPMs can be challenging, and there is no standard treatment for such difficult primary malignancies. However, the management of these conditions should be individualized using tumor board discussion and ensuring multidisciplinary coordinated care, besides considering treatment of the more aggressive malignancy before that with the less malignant potential.
同时性多原发性恶性肿瘤（MPMs）的发病率被认为非常低，其中包括实体瘤和血液系统恶性肿瘤。此外，在这种复杂情况下，脑、甲状腺和乳腺等部位的受累情况是报道最少的。在此，我们报告了五种不同类型的实体瘤，包括多形性胶质母细胞瘤、甲状腺乳头状癌、乳腺浸润性导管癌、结肠癌和胃腺癌，它们分别与五种不同的血液系统恶性肿瘤同时发生，这些血液系统恶性肿瘤依次为T细胞淋巴母细胞性非霍奇金淋巴瘤（NHL）、结内边缘区NHL、弥漫性大B细胞NHL、霍奇金淋巴瘤和胃黏膜相关淋巴组织边缘区NHL。MPMs的诊断可能具有挑战性，对于这种难治的原发性恶性肿瘤没有标准的治疗方法。然而，除了在治疗恶性潜能较低的肿瘤之前先考虑治疗侵袭性更强的恶性肿瘤外，还应通过肿瘤委员会讨论并确保多学科协调护理，对这些情况进行个体化管理。
