Mason C Y, Prieto A, Bogati H, Sannino L, Akai N, Marquardt T
Médecins Sans Frontières (MSF), Port Moresby, Papua New Guinea.
MSF, Paris, France.
Public Health Action. 2021 Mar 21;11(1):2-4. doi: 10.5588/pha.20.0026.
Evidence increasingly indicates that standardised, shorter regimens (SR) for multidrug-resistant TB (MDR-TB) is effective in treating this global disease, but there is little published data on associated adverse events. We report outcomes from a cohort treated with the SR in Port Moresby, Papua New Guinea (PNG). Among 26 patients treated with a TB SR from September 2017 to September 2018, 10 (39%) were successful treatments, 12 (46%) were failures, 2 died, and 2 were lost to follow-up. Of those whose treatment failed, most ( = 10) changed their regimen due to adverse events, including seven from ototoxicity, suggesting this SR may not be suited to all patients in PNG and similar settings.
越来越多的证据表明，针对耐多药结核病（MDR-TB）的标准化短程治疗方案（SR）在治疗这种全球性疾病方面是有效的，但关于相关不良事件的已发表数据很少。我们报告了在巴布亚新几内亚莫尔斯比港接受SR治疗的一个队列的结果。在2017年9月至2018年9月期间接受结核病SR治疗的26名患者中，10例（39%）治疗成功，12例（46%）治疗失败，2例死亡，2例失访。在治疗失败的患者中，大多数（=10）因不良事件而更改了治疗方案，其中7例是由于耳毒性，这表明该SR可能不适用于巴布亚新几内亚和类似环境中的所有患者。
