Fu Dapeng, Fang Qingbo, Yuan Fukang, Liu Junle, Ding Heyi, Chen Xuan, Cui Chaoyi, Ding Jinhui
Department of Vascular Surgery, The Second People's Hospital of Anhui, Province, Hefei, China.
Department of Vascular Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Front Chem. 2021 Mar 11;9:643411. doi: 10.3389/fchem.2021.643411. eCollection 2021.
Massive hemorrhage caused by the uncontrolled release of thrombolysis drugs is a key issue of thrombolysis therapy in clinical practice. In this study, we report a near-infrared (NIR) light-triggered drug delivery system, i.e., CuS@mSiO-PEG (CSP) nanoparticles, for the loading of a thrombolytic drug (urokinase plasminogen activators, uPA). CSP nanoparticles with the CuS nanoparticles as photothermal agents and mesoporous SiO for the loading of uPA were synthesized using a facile hydrothermal method. The CSP core-shell nanoparticles were demonstrated to possess excellent photothermal performance, exhibiting a photothermal conversion efficiency of up to 52.8%. Due to the mesoporous SiO coating, the CSP core-shell nanoparticles exhibited appropriate pore size, high pore volume, and large surface area; thus, they showed great potential to be used as drug carriers. Importantly, the release of uPA from CuS@mSiO-PEG/uPA (CSPA) carriers can be promoted by the NIR laser irradiation. The drug loading content of uPA for the as-prepared NIR-triggered drug delivery system was calculated to be 8.2%, and the loading efficiency can be determined to be as high as 89.6%. Due to the excellent photothermal effect of CSP nanocarriers, the NIR-triggered drug delivery system can be used for infrared thermal imaging . The thrombolysis assessment demonstrated that the NIR-triggered drug delivery system showed excellent thrombolytic ability under the irradiation of an 808 nm laser, showing the combined therapy for thrombolysis. As far as we know, the CSPA core-shell nanoparticles used as NIR-triggered drug delivery systems for thrombolysis have not been reported.
溶栓药物的无控制释放所导致的大量出血是临床实践中溶栓治疗的关键问题。在本研究中，我们报道了一种近红外（NIR）光触发给药系统，即CuS@mSiO-PEG（CSP）纳米颗粒，用于负载溶栓药物（尿激酶纤溶酶原激活剂，uPA）。采用简便的水热法合成了以CuS纳米颗粒作为光热剂、介孔SiO用于负载uPA的CSP纳米颗粒。结果表明，CSP核壳纳米颗粒具有优异的光热性能，光热转换效率高达52.8%。由于介孔SiO包覆，CSP核壳纳米颗粒具有合适的孔径、高孔容和大表面积；因此，它们作为药物载体具有很大的潜力。重要的是，近红外激光照射可促进uPA从CuS@mSiO-PEG/uPA（CSPA）载体中的释放。所制备的近红外触发给药系统中uPA的载药含量经计算为8.2%，载药效率高达89.6%。由于CSP纳米载体具有优异的光热效应，近红外触发给药系统可用于红外热成像。溶栓评估表明，近红外触发给药系统在808 nm激光照射下显示出优异的溶栓能力，展现了溶栓联合治疗效果。据我们所知，用作近红外触发溶栓给药系统的CSPA核壳纳米颗粒尚未见报道。
