Department of Vascular Surgery, Shanghai Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai 200011 , China.
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science , Fudan University , Shanghai 200433 , China.
ACS Appl Mater Interfaces. 2019 Nov 6;11(44):41009-41018. doi: 10.1021/acsami.9b12258. Epub 2019 Oct 22.
Inflammatory macrophage (Mφ)-mediated atherosclerosis is a leading cause of mortality and morbidity worldwide. Photothermal therapy (PTT) has been demonstrated as an efficient strategy in killing target cells, and its application in the treatment of inflammation in atherosclerosis is developing. However, the choice of nanomaterials, mechanisms, and side effects are seldom considered. In this study, semiconductor nanomaterials, that is, MoO nanoclusters, were synthesized and used for the first time in PTT for inflammatory Mφ-mediated atherosclerosis. Based on cell differential phagocytosis, the optimum amount of MoO and treatment time were selected to exert the maximum ablation effect on Mφ and minimal damage on endothelial cells without requiring additional target or selective groups. Moreover, MoO-based PTT shows an excellent therapeutic effect on atherosclerosis by eliminating Mφ in animal models, with no significant side effects observed. This study explores a new method of nanotechnology and pharmaceutical development by using and optimizing cost-effective metal oxide nanostructures in the treatment of atherosclerosis and motivates further research on minimizing the side effects of related materials.
炎性巨噬细胞 (Mφ) 介导的动脉粥样硬化是全球范围内导致死亡和发病的主要原因。光热疗法 (PTT) 已被证明是杀死靶细胞的有效策略，其在动脉粥样硬化炎症治疗中的应用正在发展。然而，纳米材料的选择、作用机制和副作用很少被考虑。在这项研究中，我们合成了半导体纳米材料，即 MoO 纳米团簇，并首次将其用于 PTT 治疗炎性 Mφ 介导的动脉粥样硬化。基于细胞差异吞噬作用，选择了最佳的 MoO 用量和治疗时间，以对 Mφ 发挥最大的消融作用，同时对内皮细胞的损伤最小，而无需额外的靶向或选择性基团。此外，基于 MoO 的 PTT 通过消除动物模型中的 Mφ 对动脉粥样硬化表现出优异的治疗效果，未观察到明显的副作用。本研究通过使用和优化具有成本效益的金属氧化物纳米结构来治疗动脉粥样硬化，探索了一种新的纳米技术和药物开发方法，并激励了进一步研究以最小化相关材料的副作用。
