Obomighie Irabonosi, Lapenas Kestutis, Murphy Billy E, Bowles Alexander M C, Bechtold Ulrike, Prischi Filippo
School of Life Sciences, University of Essex, Colchester, United Kingdom.
Front Mol Biosci. 2021 Mar 10;8:636560. doi: 10.3389/fmolb.2021.636560. eCollection 2021.
The p70 ribosomal S6 kinase (S6K) family is a group of highly conserved kinases in eukaryotes that regulates cell growth, cell proliferation, and stress response via modulating protein synthesis and ribosomal biogenesis. S6Ks are downstream effectors of the Target of Rapamycin (TOR) pathway, which connects nutrient and energy signaling to growth and homeostasis, under normal and stress conditions. The plant S6K family includes two isoforms, S6K1 and S6K2, which, despite their high level of sequence similarity, have distinct functions and regulation mechanisms. Significant advances on the characterization of human S6Ks have occurred in the past few years, while studies on plant S6Ks are scarce. In this article, we review expression and activation of the two S6K isoforms in plants and we discuss their roles in mediating responses to stresses and developmental cues.
p70核糖体S6激酶（S6K）家族是真核生物中一组高度保守的激酶，通过调节蛋白质合成和核糖体生物发生来调控细胞生长、细胞增殖和应激反应。在正常和应激条件下，S6Ks是雷帕霉素靶蛋白（TOR）途径的下游效应器，该途径将营养和能量信号与生长及体内平衡联系起来。植物S6K家族包括两种亚型，即S6K1和S6K2，尽管它们的序列相似性很高，但具有不同的功能和调控机制。在过去几年中，人类S6Ks的特性研究取得了重大进展，而关于植物S6Ks的研究却很少。在本文中，我们综述了植物中两种S6K亚型的表达和激活情况，并讨论了它们在介导应激反应和发育信号中的作用。
