Fernandez Juan P, Haider Asghar A, Materin Miguel A
Department of Ophthalmology, Duke University, Durham, NC, USA.
Am J Ophthalmol Case Rep. 2021 Mar 14;22:101059. doi: 10.1016/j.ajoc.2021.101059. eCollection 2021 Jun.
To report a clinically challenging case of a choroidal nevus with retinal invasion with accompanying ancillary testing.
A 60-year-old Caucasian female was referred for a suspicious melanocytic choroidal lesion in her left eye. Ophthalmoscopic examination revealed a melanocytic choroidal lesion, measuring 10 mm × 10 mm in basal diameter. The lesion had a clinically evident area of retinal invasion seen as a protruding choroidal mass at its center, darker in appearance compared to the rest of the lesion, obscuring retinal vessels. The choroidal nevus had associated chronic retinal changes and the absence of overlying orange pigment or subretinal fluid. On fundus autofluorescence, there was a hypoautofluorescent area showing the site of retinal invasion. Fluorescein angiography at the lesion site exhibited central blocked perfusion corresponding to the area of retinal invasion. Ultrasonography showed a dome-shaped choroidal lesion that was optically dense with a medium-high internal reflectivity measuring 3.3mm in thickness. The optical coherence tomography showed a choroidal mass extruding through a break in Bruch's membrane with inner retinal invasion. A watchful waiting strategy was adopted, and at 28 months follow-up, the choroidal lesion did not show growth or presence of new suspicious features of malignant transformation.
This case highlights the importance of recognizing the key features of choroidal nevi with retinal invasion, which can prevent the treatment of a benign condition and assist in the arrival of a correct diagnosis. These lesions should be monitored for long-term.
报告一例具有视网膜侵犯的脉络膜痣的临床挑战性病例及相关辅助检查。
一名60岁的白种女性因左眼可疑黑素细胞性脉络膜病变前来就诊。检眼镜检查发现一个黑素细胞性脉络膜病变,基底直径为10毫米×10毫米。该病变有一个临床上明显的视网膜侵犯区域,表现为病变中心突出的脉络膜肿物,外观比病变其他部分更暗,遮挡了视网膜血管。脉络膜痣伴有慢性视网膜改变,且无上方橙色色素或视网膜下液。在眼底自发荧光检查中,有一个低自发荧光区域显示视网膜侵犯部位。病变部位的荧光素血管造影显示对应于视网膜侵犯区域的中央阻塞性灌注。超声检查显示一个穹顶形脉络膜病变,光学密度高,内部反射率为中高,厚度为3.3毫米。光学相干断层扫描显示一个脉络膜肿物通过布鲁赫膜的破裂处突出并侵犯内层视网膜。采取了密切观察的策略,在28个月的随访中,脉络膜病变未显示生长或出现恶性转化的新可疑特征。
本病例强调了识别具有视网膜侵犯的脉络膜痣关键特征的重要性,这可以避免对良性病变进行治疗,并有助于做出正确诊断。这些病变应进行长期监测。