Materin Miguel A, Raducu Raluca, Bianciotto Carlos, Shields Carol L
Ophthalmic Oncology Section, Department of Ophthalmology, Yale University School of Medicine, New Haven, CT, USA.
Middle East Afr J Ophthalmol. 2010 Jul;17(3):201-6. doi: 10.4103/0974-9233.65489.
To establish the characteristics of secondary retinal and retinal pigment epithelial (RPE) changes associated with the presence of choroidal melanoma and choroidal nevus as documented by optical coherence tomography (OCT) and fundus autofluorescence (FAF).
PubMed review of major English publications examining the correlation between clinical characteristics of choroidal melanoma and nevus with OCT and FAF findings.
The intrinsic properties of choroidal melanoma, as well as overlying RPE changes, drusen, and lipofuscin are best characterized by FAF, while OCT is more sensitive for the identification of subretinal and intraretinal fluid as well as atrophy, degeneration, and photoreceptor loss in the neurosensory retina.
Secondary retinal changes associated with choroidal melanocytic lesions can be documented by OCT and FAF. OCT-evident changes are observed more often with choroidal melanoma than choroidal nevus. OCT is better suited to identify the overlying retinal detachment and edema, even before these findings are clinically apparent. FAF is most useful in documenting the presence of lipofuscin, a finding that represents one of the important criteria in differentiating small choroidal melanoma from benign choroidal nevus.
通过光学相干断层扫描（OCT）和眼底自发荧光（FAF）记录，确定与脉络膜黑色素瘤和脉络膜痣相关的继发性视网膜和视网膜色素上皮（RPE）变化的特征。
对主要英文出版物进行PubMed综述，研究脉络膜黑色素瘤和痣的临床特征与OCT及FAF检查结果之间的相关性。
脉络膜黑色素瘤的内在特性以及上方的RPE变化、玻璃膜疣和脂褐素，通过FAF能得到最佳表征，而OCT在识别视网膜下和视网膜内液以及神经感觉视网膜的萎缩、变性和光感受器丧失方面更敏感。
OCT和FAF可记录与脉络膜黑素细胞病变相关的继发性视网膜变化。脉络膜黑色素瘤比脉络膜痣更常观察到OCT明显的变化。即使在这些发现临床明显之前，OCT更适合识别上方的视网膜脱离和水肿。FAF在记录脂褐素的存在方面最有用，脂褐素的存在是区分小脉络膜黑色素瘤与良性脉络膜痣的重要标准之一。
