Ji Tingting, Li Xiaodan, Qiu Yue, Mei Lin, Jia Xinbei, Tai Jun, Guo Yongli, Zhang Jie, Wang Shengcai, Ni Xin
Department of Otolaryngology, Head and Neck Surgery Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.
Department of Otorhinolaryngology Beijing Children's Hospital Capital Institute of Pediatrics Beijing China.
Pediatr Investig. 2021 Mar 22;5(1):52-57. doi: 10.1002/ped4.12247. eCollection 2021 Mar.
Obstructive sleep apnea (OSA) is a common sleep-disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many studies have focused on OSA-related characteristics, including intermittent hypoxemia and sleep fragmentation. There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction. This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction.
阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠呼吸紊乱疾病，常导致多种合并症（如认知功能障碍），对OSA患者的生活质量产生不利影响。迄今为止，这种功能障碍的潜在机制仍不清楚。许多研究都集中在与OSA相关的特征上，包括间歇性低氧血症和睡眠片段化。越来越强调通过神经影像学研究来探索神经病理变化与认知功能障碍之间的潜在关系。本文综述了与OSA相关的认知功能障碍的最新研究进展，以揭示导致这种功能障碍的潜在机制。
