Salvador A, del Pozo E, Carlos R, Baeyens J M
Department of Pharmacology and Anaesthesia, University of Granada Medical School, Spain.
Br J Anaesth. 1988 Apr;60(5):495-9. doi: 10.1093/bja/60.5.495.
The effects were studied of several calcium channel blocking agents on muscle twitch, and possible interactions between these drugs and pancuronium and suxamethonium, using a rat phrenic-hemidiaphragm preparation. Nicardipine, verapamil and diltiazem each caused a concentration-related depression of muscle response. Nicardipine had the most, and diltiazem the least, potent effect. Verapamil and diltiazem 5 and 10 mumol litre-1 caused a concentration-dependent enhancement of suxamethonium-induced neuromuscular blockade, but increased the effect of pancuronium only at 10 mumol litre-1. Nicardipine 10 mumol litre-1 significantly enhanced pancuronium-induced neuromuscular blockade, but not that produced by suxamethonium.
采用大鼠膈神经 - 半膈肌标本，研究了几种钙通道阻滞剂对肌肉抽搐的影响，以及这些药物与泮库溴铵和琥珀胆碱之间可能的相互作用。尼卡地平、维拉帕米和地尔硫䓬均引起与浓度相关的肌肉反应抑制。尼卡地平的作用最强，地尔硫䓬的作用最弱。维拉帕米和地尔硫䓬浓度为5和10 μmol/L时，引起琥珀胆碱诱导的神经肌肉阻滞浓度依赖性增强，但仅在浓度为10 μmol/L时增加泮库溴铵的作用。尼卡地平浓度为10 μmol/L时显著增强泮库溴铵诱导的神经肌肉阻滞，但不增强琥珀胆碱诱导的神经肌肉阻滞。
