Fragen R J, Booij L H, van der Pol F, Robertson E N, Crul J F
Br J Anaesth. 1983 May;55(5):433-6. doi: 10.1093/bja/55.5.433.
In vitro studies were performed using the rat phrenic nerve-hemidiaphragm preparation to investigate possible interactions between diisopropyl phenol and its solvent, cremophor, with three neuromuscular blocking drugs. Cumulative concentration curves were constructed for the neuromuscular blockers and linear regression analyses performed. Differences in the calculated effective concentration to produce a 50% decrease in twitch height (EC50) and slope showed that diisopropyl phenol potentiated the action of suxamethonium, vecuronium (Org NC 45) and pancuronium. Cremophor potentiated the action of suxamethonium but antagonized the action of the non-depolarizing neuromuscular blockers. The possible mechanisms of action are discussed.
采用大鼠膈神经 - 半膈肌标本进行体外研究，以探讨二异丙酚及其溶剂聚氧乙烯蓖麻油与三种神经肌肉阻滞药物之间可能的相互作用。构建了神经肌肉阻滞剂的累积浓度曲线并进行线性回归分析。计算得出的使抽搐高度降低50%的有效浓度（EC50）和斜率的差异表明，二异丙酚增强了琥珀胆碱、维库溴铵（ORG NC 45）和泮库溴铵的作用。聚氧乙烯蓖麻油增强了琥珀胆碱的作用，但拮抗了非去极化神经肌肉阻滞剂的作用。讨论了可能的作用机制。
