Abouleish E
University of Texas Health Science Center, Medical School, Department of Anesthesiology, Houston 77030.
Br J Anaesth. 1988 Apr;60(5):592-4. doi: 10.1093/bja/60.5.592.
The intrathecal administration of hyperbaric morphine 1 mg for pain relief during labour was followed, 7 h after injection, and 1 h after delivery, by respiratory depression. Pulseoximetry was helpful in alerting the medical personnel. After an initial 1 mg of naloxone i.v. in increments of 0.1-0.2 mg, a continuous infusion of naloxone 0.4 mg h-1 i.v. was used to prevent a recurrence of the respiratory depression. The total dose of naloxone over an 8-h period was 3.6 mg.
分娩期间鞘内注射1毫克高压吗啡以缓解疼痛，注射后7小时及分娩后1小时出现呼吸抑制。脉搏血氧饱和度测定有助于提醒医务人员。静脉注射初始1毫克纳洛酮后，以0.1 - 0.2毫克的增量追加，随后静脉持续输注0.4毫克/小时的纳洛酮以防止呼吸抑制复发。8小时内纳洛酮的总剂量为3.6毫克。
