Scott P V, Bowen F E, Cartwright P, Rao B C, Deeley D, Wotherspoon H G, Sumrein I M
Br Med J. 1980 Aug 2;281(6236):351-3. doi: 10.1136/bmj.281.6236.351.
In 12 consecutive unselected patients admitted to a consultant maternity unit one single injection of subarachnoid morphine sulphate 1.5 mg abolished pain during the first stage of labour. Pain in the second stage was abolished in four patients and lessened in three. During the early puerperium, pain at the site of the episitotomy was much reduced. Side effects included itching of the face, nausea and vomiting, and frontal headache, but these were mild and simply treated. They were even less severe in the last four patients, in whom barbotage was not used in administering the morphine. The high rate of forceps delivery and caesarean section (three cases of each) was not thought to be associated with the use of intrathecal morphine. These findings show that intrathecal morphine can abolish the pain of labour, whether spontaneous or induced, while preserving the mother's full awareness of labour and her co-operation in the second and third stages of labour. Further, controlled, trials are warranted.
在一家顾问产科病房连续收治的12例未经挑选的患者中，单次蛛网膜下腔注射1.5毫克硫酸吗啡可消除第一产程的疼痛。4例患者第二产程的疼痛消除，3例减轻。在产褥早期，会阴切开部位的疼痛明显减轻。副作用包括面部瘙痒、恶心呕吐和前额头痛，但症状较轻且易于治疗。在最后4例未采用注入法给药吗啡的患者中，副作用甚至更轻。产钳助产和剖宫产的高发生率（各3例）被认为与鞘内注射吗啡无关。这些发现表明，鞘内注射吗啡可消除自然分娩或引产时的疼痛，同时保持母亲在分娩第二和第三阶段对分娩的充分意识及合作。此外，有必要进行对照试验。
