Worlock P, Slack R, Harvey L, Mawhinney R
Department of Orthopaedic Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK.
Br J Exp Pathol. 1988 Apr;69(2):235-44.
An experimental model of a contaminated open fracture, using the tibia of male New Zealand white rabbits, is described. Post-traumatic osteomyelitis can be reliably induced in this model, with no systemic ill-effects. The characteristic bacteriological, radiological and histological findings are described. Inoculation of the fracture site with Staphylococcus aureus in a concentration of 10(6) bacteria caused osteomyelitis in two out of five rabbits. When the concentration of inoculum was increased to 10(7) organisms, osteomyelitis was seen in four out of five rabbits. No cases of infection were seen in the control animals. This is a simple and reliable model for studies into the prevention and treatment of post-traumatic osteomyelitis.
本文描述了一种利用雄性新西兰白兔胫骨建立的开放性污染骨折实验模型。在此模型中可可靠地诱发创伤后骨髓炎，且无全身不良反应。文中描述了其特征性的细菌学、放射学和组织学表现。以每毫升含10(6)个细菌的金黄色葡萄球菌接种骨折部位，五只兔子中有两只发生骨髓炎。当接种菌浓度增至10(7)个菌时，五只兔子中有四只发生骨髓炎。对照动物未出现感染病例。这是一种用于研究创伤后骨髓炎预防和治疗的简单可靠模型。
