Csatò M, Czarnetzki B M
Department of Dermatology, University of Münster, F.R.G.
Br J Dermatol. 1988 Apr;118(4):475-9. doi: 10.1111/j.1365-2133.1988.tb02455.x.
A specific platelet activating factor (PAF) receptor antagonist, BN 52021, was tested for its efficacy in modulating DNFB-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Oral treatment of the animals in the elicitation phase of the dermatitis caused a significant suppression of DNFB-induced ear swelling. The compound was less active in croton oil-induced irritant dermatitis and ineffective when given during the sensitization phase of allergic dermatitis. The results provide indirect evidence for the involvement of PAF in the effector phase of murine contact dermatitis of the allergic type and also the irritant type to a lesser extent.
一种特异性血小板活化因子（PAF）受体拮抗剂BN 52021，在调节二硝基氟苯（DNFB）诱导的小鼠耳部过敏性接触性皮炎以及巴豆油诱导的刺激性接触性皮炎方面的疗效进行了测试。在皮炎激发期对动物进行口服治疗，可显著抑制DNFB诱导的耳部肿胀。该化合物在巴豆油诱导的刺激性皮炎中活性较低，在过敏性皮炎致敏期给药则无效。这些结果为PAF参与过敏性小鼠接触性皮炎效应期以及在较小程度上参与刺激性接触性皮炎效应期提供了间接证据。
