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血小板活化因子拮抗剂BN 52021对蒽林诱导的炎症的影响。

Effect of BN 52021, a platelet activating factor antagonist, on dithranol-induced inflammation.

作者信息

Kemény L, Csató M, Braquet P, Dobozy A

机构信息

Department of Dermatology, Albert Szent-Györgyi Medical University, Szeged, Hungary.

出版信息

Br J Dermatol. 1990 Apr;122(4):539-44. doi: 10.1111/j.1365-2133.1990.tb14731.x.

DOI:10.1111/j.1365-2133.1990.tb14731.x
PMID:2337521
Abstract

The effect of BN 52021, a selective platelet activating factor (PAF) antagonist was studied on dithranol-induced irritant dermatitis. Pretreatment of the skin with 0.45% BN 52021 ointment significantly suppressed the decrease in capillary resistance, rise in skin temperature and increase in skin-fold thickness produced by dithranol.

摘要

研究了选择性血小板活化因子（PAF）拮抗剂BN 52021对蒽林诱导的刺激性皮炎的作用。用0.45% BN 52021软膏预处理皮肤，可显著抑制蒽林引起的毛细血管阻力降低、皮肤温度升高和皮褶厚度增加。

相似文献

1
Effect of BN 52021, a platelet activating factor antagonist, on dithranol-induced inflammation.血小板活化因子拮抗剂BN 52021对蒽林诱导的炎症的影响。
Br J Dermatol. 1990 Apr;122(4):539-44. doi: 10.1111/j.1365-2133.1990.tb14731.x.
2
Effect of BN 52021, a platelet activating factor antagonist, on experimental murine contact dermatitis.血小板活化因子拮抗剂BN 52021对实验性小鼠接触性皮炎的影响。
Br J Dermatol. 1988 Apr;118(4):475-9. doi: 10.1111/j.1365-2133.1988.tb02455.x.
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Pharmacological studies on dithranol-induced irritative dermatitis in mice.地蒽酚诱导小鼠刺激性皮炎的药理学研究。
Arch Dermatol Res. 1989;281(5):362-5. doi: 10.1007/BF00412983.
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Influence of the specific antagonist of PAF-acether, BN 52021, and of Ginkgo extract on the rejection of murine tail skin allografts and the PAF-acether mortality in mice in particular consideration of the role of TXB2.血小板活化因子（PAF-乙醚）特异性拮抗剂BN 52021和银杏提取物对小鼠尾部皮肤同种异体移植排斥反应及小鼠PAF-乙醚致死率的影响，尤其考虑血栓素B2（TXB2）的作用
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Effects of the platelet-activating factor receptor antagonist BN 52021 on hematologic variables and blood loss during and after cardiopulmonary bypass.血小板活化因子受体拮抗剂BN 52021对体外循环期间及术后血液学指标和失血的影响。
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Antagonist of platelet-activating factor prevents prostaglandin E2 induced ocular hypertension in rabbits.血小板活化因子拮抗剂可预防前列腺素E2诱导的兔眼压升高。
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Influence of the specific antagonist of PAF-acether, BN 52021, on the rejection of murine tail skin allografts and the PAF-acether mortality in mice in particular consideration of the role of TXB2.
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Platelet-activating factor production during hemodialysis: effect of BN 52021.血液透析过程中血小板活化因子的产生：BN 52021的作用
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Protective effect of a specific platelet-activating factor antagonist, BN 52021, on bupivacaine-induced cardiovascular impairments in rats.一种特异性血小板活化因子拮抗剂BN 52021对布比卡因诱导的大鼠心血管损伤的保护作用。
Pharmacol Res. 1989 Sep-Oct;21(5):577-85. doi: 10.1016/1043-6618(89)90199-0.

引用本文的文献

1
PAF. A review of its effects, antagonists and possible future clinical implications (Part II).血小板活化因子。其作用、拮抗剂及未来可能的临床意义综述（第二部分）
Drugs. 1991 Aug;42(2):174-204. doi: 10.2165/00003495-199142020-00002.