Pharmaceutical department, Hospital Pharmacist Manager, Usl Umbria 1, A. Migliorati street, 06132, Perugia, Italy.
Pharmaceutical department, Clinical Pharmacologist, Usl Umbria 1, A. Migliorati street, 06132, Perugia, Italy.
Wien Klin Wochenschr. 2021 Sep;133(17-18):958-965. doi: 10.1007/s00508-021-01845-8. Epub 2021 Mar 29.
On 11 March 2020 the World Health Organization (WHO) declared a status of global pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019, COVID-19). The pandemic is currently underway, and to date has caused approximately 2.42 million deaths worldwide. The first vaccines have recently been licensed; however, research continues to identify therapeutic agents to prevent serious complications, such as anti-inflammatory, immunomodulatory, anticoagulant or antiviral agents authorized for other therapeutic indications. Epidemiological evidence shows that advanced age and comorbidities, such as diabetes, heart disease, and dyslipidemia may represent COVID-19 risk factors. In particular, in patients with hypercholesterolemia treated with statins, it is recommended that treatment should not be discontinued if COVID-19 infection occurs. The pleiotropic effects of statins are well known. In this brief review, we propose that the use of statins can potentially protect against SARS-CoV-2-induced tissue damage and improve lung function in COVID-19 patients through several pleiotropic effects. Pleiotropic effects of statins that may be a significant benefit in patients with hypercholesterolemia treated with statins and COVID-19 positive. Recent evidence shows promising results.
2020 年 3 月 11 日，世界卫生组织（WHO）宣布由新型严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）（冠状病毒病 2019，COVID-19）引起的全球大流行状况。大流行目前正在进行中，迄今为止已在全球范围内造成约 242 万人死亡。最近已经批准了第一批疫苗；然而，研究仍在继续以确定预防严重并发症的治疗剂，例如已授权用于其他治疗适应症的抗炎、免疫调节、抗凝或抗病毒药物。流行病学证据表明，高龄和合并症（如糖尿病、心脏病和血脂异常）可能是 COVID-19 的危险因素。特别是在接受他汀类药物治疗的高胆固醇血症患者中，如果发生 COVID-19 感染，建议不要停止治疗。他汀类药物的多效性作用是众所周知的。在这篇简短的综述中，我们提出他汀类药物的使用可能通过多种多效性作用来预防 SARS-CoV-2 引起的组织损伤并改善 COVID-19 患者的肺功能。他汀类药物的多效性作用可能对接受他汀类药物治疗的高胆固醇血症患者和 COVID-19 阳性患者有显著益处。最近的证据显示出有希望的结果。
