细胞外囊泡衍生的非编码 RNA 在心血管系统中的新兴作用。
Emerging Roles of Extracellular Vesicles Derived Non-Coding RNAs in the Cardiovascular System.
机构信息
Cardiac Hypertrophy Laboratory, Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.
Department of Emergency Medicine, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
出版信息
Subcell Biochem. 2021;97:437-453. doi: 10.1007/978-3-030-67171-6_17.
Cardiovascular disease is the leading cause of morbidity and mortality all over the world. Emerging evidence emphasize the importance of extracellular vesicles (EVs) in the cell to cell communication in the cardiovascular system which is majorly mediated through non-coding RNA cargo. Advancement in sequencing technologies revealed a major proportion of human genome is composed of non-coding RNAs viz., miRNAs, lncRNAs, tRNAs, snoRNAs, piRNAs and rRNAs. However, our understanding of the role of ncRNAs-containing EVs in cardiovascular health and disease is still in its infancy. This book chapter provides a comprehensive update on our understanding on the role of EVs derived ncRNAs in the cardiovascular pathophysiology and their therapeutic potential.
心血管疾病是全世界发病率和死亡率的主要原因。新出现的证据强调了细胞外囊泡（EVs）在心血管系统细胞间通讯中的重要性，主要通过非编码 RNA 货物介导。测序技术的进步揭示了人类基因组的主要部分由非编码 RNA 组成，例如 miRNA、lncRNA、tRNA、snoRNA、piRNA 和 rRNA。然而，我们对含有 ncRNA 的 EV 在心血管健康和疾病中的作用的理解仍处于起步阶段。本章全面介绍了我们对 EV 衍生 ncRNA 在心血管病理生理学中的作用及其治疗潜力的理解。
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