IEEE Trans Biomed Eng. 2021 Nov;68(11):3281-3289. doi: 10.1109/TBME.2021.3069458. Epub 2021 Oct 19.
Some proposals for oxygen uptake plateau identification are based on linear regression adaptations. However, linear regression does not adequately explain the oxygen uptake nonlinear dynamics. Recently, segmented regression was considered as an alternative to fit this dynamics, by performing an approximation by straight line segments, which provided a satisfactory fit. In this context, the non-plateau and plateau hypotheses were verified by means of a Wald-type test. This work aims to extend these proposals to scenarios with autocorrelated data.
We propose an algorithm to estimate the segmented regression model under autocorrelation using generalized least squares and suggest a bootstrap method to resample from the null distribution of Wald's statistic. The performance of the estimate and methods of the plateau diagnosis were evaluated via Monte Carlo experiments.
The empirical results show that, under autocorrelation, the proposed estimator performs better when compared to the classic method, mainly in scenarios with small sample sizes and moderate/strong autocorrelation structure. The simulations also showed that the plateau diagnosis test has a coherent empirical Type 1 Error probability and good power.
We proposed an alternative to estimate the parameters of a segmented regression model for autocorrelated data and an oxygen consumption plateau bootstrap test, and concluded the methods present good performance under simulated and applied case studies.
The proposed method was used to model real oxygen consumption data. Empirical evidence shows that the methods can be used to objectively identify the plateau in oxygen consumption only by specifying a tolerable significance level.
一些关于氧摄取平台识别的建议是基于线性回归的适应性。然而,线性回归并不能充分解释氧摄取的非线性动力学。最近,分段回归被认为是一种替代方法,可以通过直线段的近似来拟合这种动力学,从而提供了令人满意的拟合。在这种情况下,通过 Wald 型检验验证了非平台和平台假设。本研究旨在将这些建议扩展到自相关数据的场景中。
我们提出了一种在自相关情况下使用广义最小二乘法估计分段回归模型的算法,并提出了一种使用 bootstrap 方法从 Wald 统计量的零分布中重新抽样的方法。通过蒙特卡罗实验评估了估计值和平台诊断方法的性能。
实证结果表明,在自相关情况下,与经典方法相比,所提出的估计器在小样本量和中等/强自相关结构的情况下表现更好。模拟还表明,平台诊断测试具有一致的经验型 I 类错误概率和良好的功效。
我们提出了一种替代方法来估计自相关数据的分段回归模型的参数和氧耗平台 bootstrap 检验,并得出结论,所提出的方法在模拟和实际案例研究中表现良好。
该方法被用于对真实的氧耗数据进行建模。实证证据表明,通过指定可接受的显著水平,这些方法可以用于客观地识别氧摄取平台。