Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.
Psychoneuroendocrinology. 2021 May;127:105179. doi: 10.1016/j.psyneuen.2021.105179. Epub 2021 Feb 25.
Binge drinking is a highly prevalent behavior in adolescents and young adults and a risk factor to develop alcohol use disorder. Body mass index (BMI) and blood levels of leptin peptide and its soluble receptor have been implicated in alcohol use disorder; however, their role in binge drinking remains to be investigated.
We studied associations of BMI, serum levels of soluble leptin receptor (ObRe) and leptin as well as the free leptin index with binge drinking in 93 male and 99 female young adults.
In men, binge drinkers showed significantly higher BMI (kg/m) than non-binge drinkers (23.67 vs. 22.08) and higher BMI correlated significantly with more severe binge drinking episodes (ρ = 0.251). In women, we found significantly higher ObRe (ng/ml) / BMI (kg/m) values in binge drinkers than in non-binge drinkers (0.52 vs. 0.44) and ObRe/BMI values correlated significantly with more severe binge drinking episodes (ρ = 0.210).
This study confirms that higher BMI associates with binge drinking in men and shows for the first time a role of ObRe/BMI in binge drinking in women. Our data emphasize the importance of further research in the field of metabolic markers and implications in neurobiological processes of binge drinking.
狂饮是青少年和年轻人中非常普遍的行为，也是导致酒精使用障碍的危险因素。体重指数（BMI）和瘦素肽及其可溶性受体的血液水平与酒精使用障碍有关；然而，它们在狂饮中的作用仍有待研究。
我们研究了 93 名男性和 99 名女性年轻成年人的 BMI、血清可溶性瘦素受体（ObRe）和瘦素水平以及游离瘦素指数与狂饮之间的关系。
在男性中，狂饮者的 BMI（kg/m）明显高于非狂饮者（23.67 与 22.08），并且 BMI 与更严重的狂饮发作显著相关（ρ=0.251）。在女性中，我们发现狂饮者的 ObRe（ng/ml）/BMI（kg/m）值明显高于非狂饮者（0.52 与 0.44），并且 ObRe/BMI 值与更严重的狂饮发作显著相关（ρ=0.210）。
本研究证实较高的 BMI 与男性的狂饮有关，并首次显示 ObRe/BMI 在女性狂饮中的作用。我们的数据强调了进一步研究代谢标志物在狂饮神经生物学过程中的重要性。
